|A Grade 1A recommendation is a strong
recommendation, and applies to most patients in most circumstances
without reservation. Clinicians should follow a strong recommendation
unless a clear and compelling rationale for an alternative approach is
|A Grade 1 recommendation is a strong
recommendation. It means that we believe that if you follow the
recommendation, you will be doing more good than harm for most, if not
all of your patients.
|Grade A means that the best estimates
of the critical benefits and risks come from consistent data from
well-performed, randomized, controlled trials or overwhelming data of
some other form (eg, well-executed observational studies with very
large treatment effects). Further research is unlikely to have an
impact on our confidence in the estimates of benefit and risk.