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Glucocorticoid effects on the immune system

Author
W Winn Chatham, MD
Section Editors
Jordan S Orange, MD, PhD
Kieren A Marr, MD
Deputy Editors
Anna M Feldweg, MD
Anna R Thorner, MD

INTRODUCTION

Glucocorticoids (corticosteroids) have inhibitory effects on a broad range of immune responses. Because of their inhibitory effects on multiple types of immune cells, glucocorticoids are remarkably efficacious in managing many of the acute disease manifestations of inflammatory and autoimmune disorders [1].

The mechanisms of action of glucocorticoids upon the various effector cells of the immune system, as well as the effect of glucocorticoids on infection risk and vaccination, will be reviewed here. The effects of glucocorticoids on other specific physiologic systems are presented separately:

(See "Major side effects of systemic glucocorticoids".)

(See "Prevention and treatment of glucocorticoid-induced osteoporosis".)

(See "Glucocorticoid-induced myopathy".)

                                  

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Literature review current through: Apr 2017. | This topic last updated: Apr 19, 2017.
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