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Medline ® Abstract for Reference 35

of 'Gilbert syndrome and unconjugated hyperbilirubinemia due to bilirubin overproduction'

Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin.
Ellis E, Wagner M, Lammert F, Nemeth A, Gumhold J, Strassburg CP, Kylander C, Katsika D, Trauner M, Einarsson C, Marschall HU
J Hepatol. 2006;44(1):243. Epub 2005 Oct 27.
We report two patients with uncommon Gilbert's syndrome with severe unconjugated hyperbilirubinemia which was reduced from 200 to 60-90 micromol/L by long-term administration of rifampicin. Hepatic induction of bilirubin-glucuronosyltransferase was suggested by increased relative amounts of conjugated serum bilirubin. This molecular mechanism was confirmed in primary cultures of human hepatocytes.
Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska Institutet, Karolinska University Hospital-Huddinge K63, S-141 86 Stockholm, Sweden.