Gianotti-Crosti syndrome (GCS), also known as papular acrodermatitis, papular acrodermatitis of childhood, and infantile papular acrodermatitis, is a symmetric papular eruption with an acral distribution (cheeks, buttocks, and extensor surfaces of the forearms and legs) (picture 1A-F). It was first described by Gianotti in 1955, and by Crosti and Gianotti in 1957 [1,2], and was initially believed to occur only in infants and children [3-5]. It has since been reported in adults [6-8].
In the original descriptions, Gianotti-Crosti syndrome (GCS) had three cardinal manifestations [1-5]:
●Nonrelapsing erythemato-papular dermatitis localized to the face and limbs, lasting about three weeks
●Paracortical hyperplasia of lymph nodes
●Acute hepatitis, usually anicteric, which could last for months and progress to chronic liver disease