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Gestational trophoblastic neoplasia: Epidemiology, clinical features, diagnosis, staging, and risk stratification

Ross S Berkowitz, MD
Donald Peter Goldstein, MD
Neil S Horowitz, MD
Section Editors
Barbara Goff, MD
Don S Dizon, MD, FACP
Deputy Editors
Sandy J Falk, MD, FACOG
Sadhna R Vora, MD


Gestational trophoblastic neoplasia (GTN) refers to a group of malignant neoplasms that consist of abnormal proliferation of trophoblastic tissue, and may follow a hydatiform mole or a nonmolar pregnancy. GTN is comprised of the following histologic types:

Invasive mole


Placental site trophoblastic tumor (PSTT)

Epithelioid trophoblastic tumor (ETT)

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Literature review current through: Dec 2017. | This topic last updated: Sep 07, 2017.
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