Genital herpes simplex virus infection and pregnancy
- Laura E Riley, MD
Laura E Riley, MD
- Assistant Professor of Obstetrics, Gynecology and Reproductive Biology
- Harvard Medical School
- Anna Wald, MD, MPH
Anna Wald, MD, MPH
- Professor of Medicine, Epidemiology, and Laboratory Medicine
- University of Washington
- Section Editors
- Martin S Hirsch, MD
Martin S Hirsch, MD
- Editor-in-Chief — Infectious Diseases
- Section Editor — Viral Infections
- Professor of Medicine
- Harvard Medical School
- Charles J Lockwood, MD, MHCM
Charles J Lockwood, MD, MHCM
- Section Editor — Obstetrics
- Senior Vice President, USF Health
- Dean, Morsani College of Medicine
- Professor, Obstetrics and Gynecology
- University of South Florida
- Deputy Editors
- Allyson Bloom, MD
Allyson Bloom, MD
- Deputy Editor — Infectious Diseases
- Clinical Instructor in Medicine
- Harvard Medical School
- Vanessa A Barss, MD, FACOG
Vanessa A Barss, MD, FACOG
- Senior Deputy Editor — UpToDate
- Deputy Editor — Obstetrics, Gynecology and Women's Health
- Associate Clinical Professor of Obstetrics, Gynecology and Reproductive Biology
- Harvard Medical School
Herpes simplex virus (HSV) infection is prevalent worldwide among women of childbearing age. During pregnancy, the major concern of maternal HSV infection is transmission to the fetus, as neonatal infection can result in serious morbidity and mortality. The major issues related to genital herpes infection in pregnancy will be reviewed here. The epidemiology, clinical manifestations, diagnosis, treatment, and prevention of primary and recurrent genital HSV infection in the general population, and issues related to management of the infected neonate, are discussed separately:
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- CLASSIFICATION AND SIGNIFICANCE OF HSV INFECTIONS
- Primary genital infection
- First episode genital nonprimary infection
- Recurrent genital infection
- CLINICAL MANIFESTATIONS
- VERTICAL TRANSMISSION OF HSV
- Predictors of neonatal infection
- PREGNANCY MANAGEMENT
- Safety of antiviral drugs in pregnancy
- Treatment of an acute episode
- - Primary or first genital infection
- - Recurrent infection
- Suppressive therapy
- - Drug and dose
- Maternal monitoring during pregnancy
- - Evidence for cesarean delivery
- - Labor management
- SPECIAL SITUATIONS
- Preterm premature rupture of membranes
- - Recurrent HSV infection and PPROM
- - Primary or first episode genital HSV infection and PPROM
- POSTPARTUM AND NEONATAL MANAGEMENT
- SCREENING PREGNANT WOMEN WITH NO HSV HISTORY
- LINKS TO GUIDELINES FROM SELECTED NATIONAL ORGANIZATIONS
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS