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Medline ® Abstract for Reference 6

of 'Genetic counseling: Family history interpretation and risk assessment'

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Family history assessment: strategies for prevention of cardiovascular disease.
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Hunt SC, Gwinn M, Adams TD
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Am J Prev Med. 2003;24(2):136.
 
Family history assessment can be used to combine population-wide health promotion and risk-reduction efforts with a high-risk, targeted approach to help reduce the burden of cardiovascular disease (CVD). Family history is an independent predictor of CVD, and the upper portion of the family history distribution explains a larger fraction of CVD in the population than can be explained by extreme values of other risk factors (e.g., blood pressure and cholesterol). A positive family history of disease captures the underlying complexities of gene-gene and gene-environment interactions by identifying families with combinations of risk factors, both measured and unmeasured, that lead to disease expression. Family history is a useful tool for identifying most prevalent cases of CVD and for population-wide disease-prevention efforts. A positive family history also identifies the relatively small subset of families in the population at highest risk for CVD who may benefit most from targeted screening and intensive intervention.
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Cardiovascular Genetics Research Program, Department of Internal Medicine, University of Utah School of Medicine, 410 Chipeta Way, Room 167, Salt Lake City, UT 84108, USA. steve@ucvg.med.utah.edu
PMID