Medline ® Abstract for Reference 22
of 'Generalized anxiety disorder in adults: Epidemiology, pathogenesis, clinical manifestations, course, assessment, and diagnosis'
22
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Peripheral benzodiazepine binding sites on platelet membranes are increased during diazepam treatment of anxious patients.
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Weizman R, Tanne Z, Granek M, Karp L, Golomb M, Tyano S, Gavish M
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Eur J Pharmacol. 1987;138(2):289.
Reduced (24%) [3H]PK 11195 binding capacity to platelet membranes was observed in anxious patients in comparison to age- and sex-matched normal controls. Four weeks of diazepam treatment induced elevation (69%) in the maximal number of binding sites, and 1 week of drug withdrawal resulted in a slight decrease (16%) in 'peripheral' benzodiazepine binding sites as compared to their level during treatment.
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PMID