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Fondaparinux: Dosing and adverse effects

Kenneth A Bauer, MD
Section Editor
Lawrence LK Leung, MD
Deputy Editor
Jennifer S Tirnauer, MD


Fondaparinux (Arixtra) is a synthetic anticoagulant based on the pentasaccharide sequence that makes up the minimal antithrombin (AT) binding region of heparin. Similar to low molecular weight heparins, it is an indirect inhibitor of factor Xa, but it does not inhibit thrombin at all. Fondaparinux has a longer half-life than heparin and does not bind platelets, both of which may be advantageous in certain settings.

This topic review discusses the dosing and adverse effects associated with fondaparinux, including dosing in patients with renal insufficiency and management of bleeding.

Indications for fondaparinux are presented in separate topic reviews:

Deep vein thrombosis and pulmonary embolism – (See "Venous thromboembolism: Initiation of anticoagulation (first 10 days)".)

Superficial vein thrombosis – (See "Phlebitis and thrombosis of the superficial lower extremity veins".)

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Literature review current through: Nov 2017. | This topic last updated: May 31, 2016.
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