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Medline ® Abstract for Reference 54

of 'Fluoropyrimidine-associated cardiotoxicity: Incidence, clinical manifestations, mechanisms, and management'

Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina.
Stewart T, Pavlakis N, Ward M
Intern Med J. 2010;40(4):303.
In this case series we present a variety of different cardiac toxicities with 5-fluorouracil and its pro-drug capecitabine, including myocardial infarction, cardiomyopathy, sinoatrial and atrioventricular node dysfunction, takotsubo cardiomyopathy and QT prolongation with torsade-de pointes ventricular tachycardia. We stress the fact that while vasospasm is a well-recognized side-effect of this class of chemotherapeutic agent, broader cardiotoxicity is commonly seen and an increased awareness of the range of toxicity is necessary if repeat toxicity is to be avoided.
Department of Cardiology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.