Medline ® Abstract for Reference 53
of 'Fluoropyrimidine-associated cardiotoxicity: Incidence, clinical manifestations, mechanisms, and management'
Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil.
Talapatra K, Rajesh I, Rajesh B, Selvamani B, Subhashini J
J Cancer Res Ther. 2007 Jul-Sep;3(3):169-71.
The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent. Although various other cardiac events have been reported in literature, a series of patients having transient asymptomatic bradycardia has not been reported in the literature as yet. We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU. We plan to do a Holter study during the period of bradycardia in subsequent patients and this may throw more light on the issue.
Department of Radiation Oncology, Unit 2, Christian Medical College, Vellore - 430 002, India.