Medline ® Abstract for Reference 52
of 'Fluoropyrimidine-associated cardiotoxicity: Incidence, clinical manifestations, mechanisms, and management'
The spectrum of 5-fluorouracil cardiotoxicity.
Dalzell JR, Samuel LM
Anticancer Drugs. 2009;20(1):79.
Cardiotoxicity is a rare but serious complication of 5-fluorouracil therapy. Coronary vasospasm and, less frequently, acute myocarditis have been identified as underlying mechanisms. We report a case of severe toxicity in a relatively young and fit male patient being treated for metastatic colonic adenocarcinoma displaying characteristics that cannot be explained by either mechanism alone.
Department of Cardiology, Western Infirmary, Glasgow G11 6NT, UK. firstname.lastname@example.org