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Medline ® Abstracts for References 39,51-55

of 'Fluoropyrimidine-associated cardiotoxicity: Incidence, clinical manifestations, mechanisms, and management'

39
TI
Severe ventricular dysrhythmias and silent ischemia during infusion of the antimetabolite 5-fluorouracil and cis-platin.
AU
Hrovatin E, Viel E, Lestuzzi C, Tartuferi L, Zardo F, Brieda M, Dametto E, Piazza R, Antonini-Canterin F, Vaccher E, Meneguzzo N, Nicolosi GL
SO
J Cardiovasc Med (Hagerstown). 2006 Aug;7(8):637-40.
 
The antimetabolite 5-fluorouracil is frequently used in the therapy of various malignancies. Cardiotoxicity has frequently been described during treatment, but there is no common agreement on the need to perform cardiovascular monitoring of patients during 5-fluorouracil administration. We report the case of a young patient with an head-neck cancer on whom a continuous electrocardiogram recording was performed, documenting serious ventricular dysrhythmias in the presence of myocardial ischemia during 5-fluorouracil and cis-platin infusion.
AD
UO Cardiologia-ARC, Dip. Emergenza, AO SM degli Angeli, Italy. e.hrovatin@tin.it
PMID
51
TI
Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis.
AU
Çalık AN,Çeliker E, Velibey Y,ÇağdaşM, GüzelburçÖ
SO
Am J Emerg Med. 2012 Jan;30(1):257.e1-3. Epub 2011 Jan 3.
 
5-Fluorouracil (5-FU) has a significant antineoplastic activity and has been used for the management of various malignant neoplasms. Cardiotoxicity of 5-FU is rare but may be life-threatening. A 55-year-old female patient was admitted to our hospital with atypical chest pain. Her electrocardiogram revealed widespread ST-segment elevations, and she had an elevated troponin level. Transthoracic echocardiography revealed global myocardial hypokinesia with impaired left ventricular systolic function (ejection fraction, 20%). Coronary angiography revealed normal coronary arteries with no vasospasm, and therefore, she was hospitalized with the diagnosis of acute toxic myopericarditis and was treated medically. In literature, this case is the first case of acute toxic myocarditis occurring because of the first dose of 5-FU.
AD
Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, Turkey.
PMID
52
TI
The spectrum of 5-fluorouracil cardiotoxicity.
AU
Dalzell JR, Samuel LM
SO
Anticancer Drugs. 2009;20(1):79.
 
Cardiotoxicity is a rare but serious complication of 5-fluorouracil therapy. Coronary vasospasm and, less frequently, acute myocarditis have been identified as underlying mechanisms. We report a case of severe toxicity in a relatively young and fit male patient being treated for metastatic colonic adenocarcinoma displaying characteristics that cannot be explained by either mechanism alone.
AD
Department of Cardiology, Western Infirmary, Glasgow G11 6NT, UK. j.dalzell@nhs.net
PMID
53
TI
Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil.
AU
Talapatra K, Rajesh I, Rajesh B, Selvamani B, Subhashini J
SO
J Cancer Res Ther. 2007 Jul-Sep;3(3):169-71.
 
The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent. Although various other cardiac events have been reported in literature, a series of patients having transient asymptomatic bradycardia has not been reported in the literature as yet. We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU. We plan to do a Holter study during the period of bradycardia in subsequent patients and this may throw more light on the issue.
AD
Department of Radiation Oncology, Unit 2, Christian Medical College, Vellore - 430 002, India.
PMID
54
TI
Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina.
AU
Stewart T, Pavlakis N, Ward M
SO
Intern Med J. 2010;40(4):303.
 
In this case series we present a variety of different cardiac toxicities with 5-fluorouracil and its pro-drug capecitabine, including myocardial infarction, cardiomyopathy, sinoatrial and atrioventricular node dysfunction, takotsubo cardiomyopathy and QT prolongation with torsade-de pointes ventricular tachycardia. We stress the fact that while vasospasm is a well-recognized side-effect of this class of chemotherapeutic agent, broader cardiotoxicity is commonly seen and an increased awareness of the range of toxicity is necessary if repeat toxicity is to be avoided.
AD
Department of Cardiology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.
PMID
55
TI
Rechallenging 5-Fluorouracil in a Patient With Capecitabine-Induced Ventricular Fibrillation.
AU
Lai S, Marshall JL, Morrissey RL
SO
Clin Colorectal Cancer. 2015 Sep;14(3):198-201. Epub 2015 Mar 6.
 
AD
Division of Hematology and Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC. Electronic address: laisueyi@gmail.com.
PMID