Medline ® Abstract for Reference 19
of 'Fluoropyrimidine-associated cardiotoxicity: Incidence, clinical manifestations, mechanisms, and management'
Myocardial ischemia induced by topical use of 5-fluorouracil.
Rozenman Y, Gurewich J, Gotsman MS
Int J Cardiol. 1995;49(3):282.
An 85-year-old woman, with known stable angina pectoris, was prescribed 5-fluorouracil cream to treat a small basal cell carcinoma on the forehead. Half an hour after application the patient developed her typical ischemic pain which persisted for 2 hours. Rechallenge, during hospitalization, resulted in recurrence of symptoms that were effectively controlled with sublingual isosorbide dinitrate. Prophylactic therapy with nitroglycerin patch enabled further use of the 5-fluorouracil cream for the next month.
Department of Cardiology, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel.