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Medline ® Abstract for Reference 19

of 'Fluoropyrimidine-associated cardiotoxicity: Incidence, clinical manifestations, mechanisms, and management'

19
TI
Myocardial ischemia induced by topical use of 5-fluorouracil.
AU
Rozenman Y, Gurewich J, Gotsman MS
SO
Int J Cardiol. 1995;49(3):282.
 
An 85-year-old woman, with known stable angina pectoris, was prescribed 5-fluorouracil cream to treat a small basal cell carcinoma on the forehead. Half an hour after application the patient developed her typical ischemic pain which persisted for 2 hours. Rechallenge, during hospitalization, resulted in recurrence of symptoms that were effectively controlled with sublingual isosorbide dinitrate. Prophylactic therapy with nitroglycerin patch enabled further use of the 5-fluorouracil cream for the next month.
AD
Department of Cardiology, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel.
PMID