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Factor XI deficiency

Caroline Bérubé, MD
Section Editor
Lawrence LK Leung, MD
Deputy Editor
Jennifer S Tirnauer, MD


Factor XI (FXI) is a plasma glycoprotein that participates in the contact phase of blood coagulation (ie, the intrinsic pathway). Unlike the other contact factors (ie, high molecular weight kininogen, factor XII, prekallikrein), FXI is important for normal hemostasis in vivo. It plays an important role in the amplification of the initial coagulation response via a positive feedback mechanism for the generation of additional thrombin.

The diagnosis and management of factor XI deficiency are discussed here.

Separate topic reviews discuss other inherited and acquired factor deficiencies, and a general approach to the patient with unexplained bleeding or abnormal coagulation testing:

Unexplained bleeding – (See "Approach to the child with bleeding symptoms" and "Approach to the adult patient with a bleeding diathesis".)

Unexplained prolonged aPTT – (See "Clinical use of coagulation tests".)

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Literature review current through: Sep 2017. | This topic last updated: Aug 01, 2016.
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