Medline ® Abstract for Reference 89
of 'Extravasation injury from chemotherapy and other non-antineoplastic vesicants'
Mediastinal infusion of epirubicin and 5-fluorouracil. A complication of totally implantable central venous systems. Report of a case.
Rodier JM, Malbec L, Lauraine EP, Batel-Copel L, Bernadou A
J Cancer Res Clin Oncol. 1996;122(9):566.
Perforation of the wall of the superior vena cava by a central venous catheter is reported. The resultant inadvertent infusion of 5-fluorouracil and epirubicin caused a severe acute inflammatory reaction in the right-lobe bronchus, mediastinal infiltration and pleural and pericardial effusions. The patient recovered but has residual mild oesophageal dysfunction.
Department of Internal Medicine-Oncology, Hotel-Dieu, Paris, France.