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Medline ® Abstract for Reference 67

of 'Extravasation injury from chemotherapy and other non-antineoplastic vesicants'

67
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Accidental intramuscular injection of mechlorethamine.
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Owen OE, Dellatorre DL, Van Scott EJ, Cohen MR
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Cancer. 1980;45(8):2225.
 
A 55-year-old man with chronic, active diffuse psoriasis was accidentally given 30 mg of mechlorethmine deep into the buttock muscles. About 5 hours after the intramuscular (IM) mechlorethamine injection, 1/6 M sodium thiosulfate was infused around the intramuscular site. Although systemic responses to the mechlorethamine developed, the expected muscular and adjacent skin destruction did not occur. Instead, IM mechlorethamine induced only minimal local tenderness.
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PMID