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Extrapulmonary manifestations of sarcoidosis

Talmadge E King, Jr, MD
Section Editor
Kevin R Flaherty, MD, MS
Deputy Editor
Helen Hollingsworth, MD


Sarcoidosis is a multisystem granulomatous disorder of unknown etiology that affects individuals worldwide and is characterized pathologically by the presence of noncaseating granulomas in involved organs. It typically affects young adults and initially presents with one or more of the following abnormalities:

Bilateral hilar adenopathy

Pulmonary reticular opacities

Skin, joint, and/or eye lesions

Sarcoidosis can involve all organ systems to a varying extent and degree [1,2]. An overview of the clinical manifestations and diagnosis of extrapulmonary sarcoidosis will be reviewed here. Issues relating to pulmonary sarcoidosis, or the epidemiology, pathogenesis, and treatment of sarcoidosis are discussed separately. (See "Clinical manifestations and diagnosis of pulmonary sarcoidosis" and "Pathology and pathogenesis of sarcoidosis" and "Treatment of pulmonary sarcoidosis: Initial therapy with glucocorticoids" and "Treatment of pulmonary sarcoidosis: Disease refractory to glucocorticoid therapy".)

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Literature review current through: Oct 2017. | This topic last updated: Jun 30, 2017.
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