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Extragonadal germ cell tumors involving the mediastinum and retroperitoneum

Philip W Kantoff, MD
Section Editor
William K Oh, MD
Deputy Editors
Michael E Ross, MD
Helen Hollingsworth, MD


Germ cell tumors (GCTs) are classified as extragonadal if there is no evidence of a primary tumor in the testes or ovaries [1].

Extragonadal GCTs typically arise in midline locations, and specific sites vary with age. In adults, the most common sites, in order of frequency, are the anterior mediastinum, the retroperitoneum, and the pineal and suprasellar regions. In infants and young children, sacrococcygeal and intracranial GCTs are most common.

Mediastinal and retroperitoneal GCTs are reviewed here. Related topics include:

(See "Approach to the adult patient with a mediastinal mass".)

(See "Pathology of mediastinal tumors".)

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Literature review current through: Nov 2017. | This topic last updated: Jun 13, 2017.
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