Medline ® Abstract for Reference 27
of 'Exercise in the treatment and prevention of hypertension'
27
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Exercise-induced hypertension, endothelial dysfunction, and coronary artery disease in a marathon runner.
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Goel R, Majeed F, Vogel R, Corretti MC, Weir M, Mangano C, White C, Plotnick GD, Miller M
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Am J Cardiol. 2007 Mar;99(5):743-4. Epub 2007 Jan 11.
Aerobic activity performed on a regular basis is 1 of several lifestyle recommendations endorsed to reduce risk of coronary disease. However, 1 potential concern of arduous aerobic activity is exercise-induced hypertension. This is the first case to our knowledge, of accelerated coronary calcification in an otherwise asymptomatic middle-aged male marathon runner devoid of traditional cardiovascular risk factors. As a consequence of exercise-induced hypertension and associated oxidative stress, improvement of endothelial dysfunction occurred after antioxidant supplementation. In conclusion, vigorous aerobic activity in susceptible individuals may promote oxidative stress and coronary atherosclerosis.
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Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
PMID