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Medline ® Abstract for Reference 61

of 'Evaluation of the infant with atypical genitalia (disorder of sex development)'

FSH Injections and Ultrasonography Determine Presence of Ovarian Components in the Evaluation of Ovotesticular Disorders of Sex Development.
French S, Rodriguez L, Schlesinger A, McCullough L, Dietrich J, Hicks J, Karaviti L
Int J Pediatr Endocrinol. 2009;2009:507964. Epub 2010 Jan 17.
Three infants with ambiguous genitalia and suspected ovotestes were given recombinant FSH to induce ovarian follicular development. The development of follicles in the gonadal tissue suggested the presence of ovarian tissue in two of the three infants. This method may provide a means to better characterize gonadal anatomy in patients affected by disorders of sex development (DSD). Sonographic information poststimulation provided parents with earlier and more specific education and support concerning the possible need for confirmative gonadal biopsy treatment options.
Department of Pediatrics, Division of Diabetes and Endocrinology, Gender Medicine Team, Baylor College of Medicine, Houston, TX 77030, USA.