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Evaluation and staging of non-Hodgkin lymphoma

Authors
Arnold S Freedman, MD
Jonathan W Friedberg, MD
Section Editor
Andrew Lister, MD, FRCP, FRCPath, FRCR
Deputy Editor
Alan G Rosmarin, MD

INTRODUCTION

The initial evaluation of the patient with newly diagnosed non-Hodgkin lymphoma (NHL) must establish the precise histologic subtype, the extent and sites of disease (localized or advanced; nodal or extranodal), and the general health status of the patient. These studies help to determine the appropriate therapy and the patient's prognosis.

A general review of the initial laboratory studies, imaging studies, staging, and prognosis of NHL will be presented here. Of note, the appropriate pretreatment evaluation differs by histologic subtype. As such, details regarding the pretreatment evaluation of many NHL histologies are presented separately as part of the discussion of their initial treatment. The clinical presentation and basic diagnostic tests are presented separately as well. (See "Clinical presentation and diagnosis of non-Hodgkin lymphoma" and "Classification of the hematopoietic neoplasms".)

INITIAL LABORATORY STUDIES

Overview — After the initial tissue biopsy provides a diagnosis of NHL, the following baseline laboratory tests are appropriate for most histologies:

Complete blood count, white blood cell differential, platelet count, and examination of the peripheral smear for the presence of atypical cells, suggesting peripheral blood and bone marrow involvement

Biochemical tests including blood urea nitrogen (BUN), creatinine, alkaline phosphatase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and albumin

                               

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Literature review current through: Nov 2016. | This topic last updated: Wed Feb 03 00:00:00 GMT+00:00 2016.
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