Medline ® Abstract for Reference 58
of 'Evaluation and management of drug-resistant epilepsy'
58
TI
Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy.
AU
Tan NC, Heron SE, Scheffer IE, Pelekanos JT, McMahon JM, Vears DF, Mulley JC, Berkovic SF
SO
Neurology. 2004;63(6):1090.
Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.
AD
Epilepsy Research Centre and Department of Medicine (Neurology), University of Melbourne, USA.
PMID