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Medline ® Abstract for Reference 55

of 'Etiology of acute pancreatitis'

Drug-associated pancreatitis: facts and fiction.
Rünzi M, Layer P
Pancreas. 1996;13(1):100.
In the past, numerous reports on drugs probably causing acute pancreatitis have been published. However, most of these case reports were anecdotal with a lack of obvious evidence and did not present a comprehensive summary. Although drug-associated pancreatitis is rare, it is gaining increasing importance with the introduction of several potent new agents, i.e., anti-acquired immunodeficiency syndrome drugs. The following comprehensive review scrutinizes the evidence present in the world literature on drugs associated with acute or chronic pancreatitis and, based on this, categorizes in a definite, probable, or possible causality. In addition, explanations for the pathophysiological mechanisms are discussed.
Department of Medicine, University of Essen, Germany.