Medline ® Abstract for Reference 4
of 'Etiology, clinical features, and diagnosis of neonatal hypertension'
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Evolving blood pressure dynamics for extremely preterm infants.
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Batton B, Li L, Newman NS, Das A, Watterberg KL, Yoder BA, Faix RG, Laughon MM, Stoll BJ, Higgins RD, Walsh MC
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J Perinatol. 2014 Apr;34(4):301-5. Epub 2014 Feb 06.
Objective:To examine changes in arterial blood pressure (ABP) after birth in extremely preterm infants.Study Design:Prospective observational study of infants 23(0/7) to 26(6/7) weeks gestational age (GA). Antihypotensive therapy use and ABP measurements were recorded for the first 24 h.Result:A cohort of 367 infants had 18 709 ABP measurements recorded. ABP decreased for the first 3 h, reached a nadir at 4 to 5 h and then increased at an average rate of 0.2 mm Hg h(-1). The rise in ABP from hour 4 to 24 was similar for untreated infants (n=164) and infants given any antihypotensive therapy (n=203), a fluid bolus (n=135) or dopamine (n=92). GA-specific trends were similar. ABP tended to be lower as GA decreased, but varied widely at each GA.Conclusion:ABP increased spontaneously over the first 24 postnatal hours for extremely preterm infants. The rate of rise in ABP did not change with antihypotensive therapy.
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1]Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA [2]Department of Pediatrics, Southern Illinois University School of Medicine, Springfield, IL, USA.
PMID