Medline ® Abstract for Reference 10
of 'Etiology and diagnosis of distal (type 1) and proximal (type 2) renal tubular acidosis'
Hypokalaemia and Renal Tubular Acidosis due to Abuse of Nurofen Plus.
Blackstock MJ, Lee A
Case Rep Crit Care. 2012;2012:141505. Epub 2012 8 29.
Nurofen Plus is a common analgesic containing ibuprofen and codeine. We present a case of a 38-year-old lady who developed renal tubular acidosis with severe hypokalaemia, after chronic abuse of Nurofen Plus tablets. She presented with confusion and profound biochemical abnormalities requiring critical care admission for electrolyte replacement. Ibuprofen causes renal tubular acidosis due to its effects on carbonic anhydrase activity.
Critical Care, Anaesthesia and Pain Management Department, Royal Infirmary of Edinburgh 51 Little France Crescent, Edinburgh EH16 4SA, UK.