Estrogen and cognitive function
- Fran Grodstein, ScD
Fran Grodstein, ScD
- Professor of Medicine
- Harvard Medical School
- Section Editors
- Robert L Barbieri, MD
Robert L Barbieri, MD
- Editor-in-Chief — Obstetrics, Gynecology and Women's Health
- Section Editor — General Gynecology and Female Reproductive Endocrinology
- Kate Macy Ladd Professor of Obstetrics, Gynecology and Reproductive Biology
- Harvard Medical School
- William F Crowley, Jr, MD
William F Crowley, Jr, MD
- Section Editor — Female Reproductive Endocrinology
- Daniel K Podolsky Professor of Medicine
- Harvard Medical School
The role of estrogen and menopausal hormone therapy (MHT) in cognitive function and Alzheimer disease (the major cause of dementia) has attracted considerable scientific and public interest. Finding a means to delay the onset of dementia is of substantial public health significance because approximately 5 percent of United States women over 60 years of age have dementia; this rises to 12 percent after age 75 years and 28 percent over age 85 years. In addition, the prevalence of dementia will increase markedly in coming years since older adults are the fastest-growing segment of the population.
This topic review will discuss the biologic basis for the hypothesis that estrogen is related to cognitive function and/or Alzheimer disease. Individual areas that will be explored are the role of estrogen in the following:
●Maintenance of cognitive function in nondemented women
●Prevention of Alzheimer disease
●Treatment of women with Alzheimer diseaseTo continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- ESTROGEN AND COGNITIVE FUNCTION
- Biologic basis
- Epidemiologic evidence
- - Effect of endogenous estrogen
- - Effect of exogenous estrogen
- Clinical trial evidence
- - Younger menopausal women
- ESTROGEN AND DEMENTIA
- Epidemiologic studies
- - Timing of exposure
- Clinical trial data
- - Recently menopausal women
- Treatment of dementia
- SUMMARY AND RECOMMENDATIONS