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Epidermodysplasia verruciformis

Authors
Peter Itin, MD
Bettina Burger, DSc
Section Editor
Jonathan A Dyer, MD
Deputy Editor
Rosamaria Corona, MD, DSc

INTRODUCTION

Epidermodysplasia verruciformis (EV, MIM #226400) is a rare autosomal recessive skin disease characterized by an abnormally high susceptibility to infection with certain types of human papillomavirus (HPV) called EV-HPV, mostly beta-HPV [1-5]. Patients have disseminated polymorphic lesions, including flat-topped, wart-like papules and pityriasis versicolor-like macules, predominantly on skin areas exposed to sunlight. In addition, patients with EV have an increased risk of developing nonmelanoma skin cancers, mainly cutaneous squamous cell carcinomas, at an early age [6-9].

This topic will discuss the pathogenesis, clinical manifestations, diagnosis, and treatment of epidermodysplasia verruciformis. The epidemiology, virology, and natural history of HPV infection are discussed separately.

(See "Epidemiology of human papillomavirus infections".)

(See "Virology of human papillomavirus infections and the link to cancer".)

(See "The life cycle, natural history, and immunology of human papillomaviruses".)

                    

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Literature review current through: Nov 2016. | This topic last updated: Tue Sep 01 00:00:00 GMT+00:00 2015.
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References
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