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Epidemiology, pathogenesis, and etiology of kidney disease in multiple myeloma and other monoclonal gammopathies

Nelson Leung, MD
Gerald B Appel, MD
S Vincent Rajkumar, MD
Section Editors
Richard J Glassock, MD, MACP
Robert A Kyle, MD
Deputy Editor
Albert Q Lam, MD


Kidney disease is a common complication of monoclonal gammopathies including multiple myeloma. A wide range of renal manifestations and pathologies involving different mechanisms have been described with these disorders [1-6].

This topic will review the epidemiology, pathogenesis, and etiology of kidney disease in multiple myeloma and other monoclonal gammopathies. The clinical features, evaluation, diagnosis, and treatment of kidney disease in multiple myeloma and other monoclonal gammopathies are discussed separately. (See "Clinical features, evaluation, and diagnosis of kidney disease in multiple myeloma and other monoclonal gammopathies" and "Treatment and prognosis of kidney disease in multiple myeloma and other monoclonal gammopathies".)


Kidney disease in multiple myeloma — Kidney disease is one of the most common complications in multiple myeloma. The reported frequency of kidney impairment in multiple myeloma varies depending upon the definition used [6-11]:

Approximately 50 percent of patients with multiple myeloma experience acute kidney injury (AKI) or chronic kidney disease (CKD) at some time during the course of their disease [7].

Among newly diagnosed patients, 20 to 50 percent have AKI or CKD at the time of diagnosis [6,8,9,11,12].

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Literature review current through: Oct 2017. | This topic last updated: Nov 09, 2016.
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