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Epidemiology of malignant pleural mesothelioma

Daniel H Sterman, MD
Leslie A Litzky, MD
Larry R Kaiser, MD
Section Editors
Andrew Nicholson, MD
James R Jett, MD
Rogerio C Lilenbaum, MD, FACP
Joseph S Friedberg, MD
Deputy Editor
Sadhna R Vora, MD


Mesothelioma is an insidious neoplasm arising from the mesothelial surfaces of the pleural and peritoneal cavities, the tunica vaginalis, or the pericardium. Eighty percent of cases are pleural in origin. The predominant cause of malignant mesothelioma is inhalational exposure to asbestos, with approximately 70 percent of cases of pleural mesothelioma being associated with documented asbestos exposure.

This topic will discuss the epidemiology and risk factors of pleural mesothelioma.

The pathology, clinical presentation, evaluation, and staging, and treatment of malignant pleural mesothelioma are discussed separately. (See "Presentation, initial evaluation, and prognosis of malignant pleural mesothelioma" and "Pathology of malignant pleural mesothelioma" and "Initial management of malignant pleural mesothelioma".)

Peritoneal mesothelioma is discussed separately. (See "Malignant peritoneal mesothelioma: Epidemiology, risk factors, clinical presentation, diagnosis, and staging" and "Malignant peritoneal mesothelioma: Treatment".)


The annual incidence of mesothelioma in the United States is estimated to be approximately 3300 cases per year [1]. The incidence of mesothelioma in the United States peaked around the year 2000 and is now declining, secondary to control of exposure to asbestos [2].


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Literature review current through: Sep 2016. | This topic last updated: Sep 12, 2016.
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