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Epidemiology, clinical manifestations, pathologic features, and diagnosis of diffuse large B cell lymphoma


Diffuse large B cell lymphoma (DLBCL) is the most common histologic subtype of non-Hodgkin lymphoma (NHL) accounting for approximately 25 percent of NHL cases [1,2]. (See "Classification of the hematopoietic neoplasms".)

It is increasingly appreciated that the diagnostic category of "DLBCL" is quite heterogeneous in terms of morphology, genetics, and biologic behavior. A number of clinicopathologic entities are now recognized that are sufficiently distinct to be considered separate diagnostic categories:

T cell histiocyte rich large B cell lymphoma. (See 'T cell histiocyte rich large B cell lymphoma' below.)

Primary DLBCL of the mediastinum, also called primary mediastinal large B cell lymphoma. (See "Primary mediastinal large B cell lymphoma".)

Intravascular lymphoma. (See "Intravascular large cell lymphoma".)


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Literature review current through: Mar 2014. | This topic last updated: Feb 14, 2014.
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