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Epidemiology, clinical manifestations, and diagnosis of Scedosporium and Lomentospora infections

Sylvia F Costa, MD
Barbara D Alexander, MD, MHS
Section Editor
Carol A Kauffman, MD
Deputy Editor
Anna R Thorner, MD


During the past few decades, opportunistic fungal pathogens have become increasingly recognized as a cause of infection in severely ill or immunocompromised patients [1,2]. Although Aspergillus species remain the most common mold to cause invasive infection, other mold infections are becoming more common [1-3]. Two of these, Scedosporium apiospermum and Lomentospora prolificans, are considered major human pathogens [4].

The epidemiology, clinical manifestations, and diagnosis of Scedosporium and Lomentospora infections will be reviewed here. The treatment of these infections is discussed elsewhere. (See "Treatment of Scedosporium and Lomentospora infections".)


Scedosporium apiospermum complex — S. apiospermum [5] is the asexual form (anamorph) of Pseudallescheria boydii [6-9]. Colonies grow rapidly and have a cottony appearance on cornmeal agar; with age, the colonies become gray or brown in color (picture 1). The hyphal forms appear as branching septate hyphae with a single terminal conidia, which is uninucleate and cylindrical in shape (picture 2) [10].

When the sexual form of S. apiospermum is present in culture, the organism is identified as P. boydii. Dark, spherical structures, known as cleistothecia, characterize the sexual form of this organism (picture 3) [11].

S. apiospermum complex has been recognized to encompass several distinct species. Through the use of molecular phylogeny, the following species have been accepted as unique: Pseudallescheria apiosperma (anamorph S. apiospermum), Scedosporium aurantiacum, P. boydii (Scedosporium boydii), Scedosporium dehoogii, and Pseudallescheria minutispora [12]. Identification to the species level is of interest since the susceptibility patterns differ among members of the S. apiospermum complex. (See "Treatment of Scedosporium and Lomentospora infections", section on 'Scedosporium aurantiacum'.)

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Literature review current through: Oct 2017. | This topic last updated: Oct 24, 2017.
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  1. Groll AH, Walsh TJ. Uncommon opportunistic fungi: new nosocomial threats. Clin Microbiol Infect 2001; 7 Suppl 2:8.
  2. Perfect JR, Schell WA. The new fungal opportunists are coming. Clin Infect Dis 1996; 22 Suppl 2:S112.
  3. Husain S, Alexander BD, Munoz P, et al. Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi. Clin Infect Dis 2003; 37:221.
  4. Panackal AA, Marr KA. Scedosporium/Pseudallescheria infections. Semin Respir Crit Care Med 2004; 25:171.
  5. Castellani A, Chalmers AJ. Scedosporium apiospermum. In: Manual of Tropical Medicine, 3rd ed, Baillere, Tindall & Cox, London 1919.
  6. McGinnis MR, Padhye AA, Ajello L. Pseudallescheria Negroni et Fischer, 1943 and its later synonym Petriellidium Malloch, 1970. Mycotaxon 1982; 14:94.
  7. de Hoog GS, Marvin-Sikkema FD, Lahpoor GA, et al. Ecology and physiology of the emerging opportunistic fungi Pseudallescheria boydii and Scedosporium prolificans. Mycoses 1994; 37:71.
  8. Rainer J, de Hoog GS, Wedde M, et al. Molecular variability of Pseudallescheria boydii, a neurotropic opportunist. J Clin Microbiol 2000; 38:3267.
  9. Gilgado F, Cano J, Gené J, Guarro J. Molecular phylogeny of the Pseudallescheria boydii species complex: proposal of two new species. J Clin Microbiol 2005; 43:4930.
  10. Salkin IF, McGinnis MR, Dykstra MJ, Rinaldi MG. Scedosporium inflatum, an emerging pathogen. J Clin Microbiol 1988; 26:498.
  11. Walsh TJ, Groll A, Hiemenz J, et al. Infections due to emerging and uncommon medically important fungal pathogens. Clin Microbiol Infect 2004; 10 Suppl 1:48.
  12. Lackner M, de Hoog GS, Verweij PE, et al. Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species. Antimicrob Agents Chemother 2012; 56:2635.
  13. Delhaes L, Harun A, Chen SC, et al. Molecular typing of Australian Scedosporium isolates showing genetic variability and numerous S. aurantiacum. Emerg Infect Dis 2008; 14:282.
  14. Kaur J, Duan SY, Vaas LA, et al. Phenotypic profiling of Scedosporium aurantiacum, an opportunistic pathogen colonizing human lungs. PLoS One 2015; 10:e0122354.
  15. Heath CH, Slavin MA, Sorrell TC, et al. Population-based surveillance for scedosporiosis in Australia: epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection. Clin Microbiol Infect 2009; 15:689.
  16. Malloch D, Salkin IF. A new species of Scedosporium associated with osteomyelitis in humans. Mycotaxon 1984; 21:247.
  17. Lackner M, Sybren de Hoog, Yang L, et al. Proposed nomenclature for Pseudallescheria, Scedosporium and related genera. Fungal Diversity 2014; 67:1.
  18. Lennon PA, Cooper CR Jr, Salkin IF, Lee SB. Ribosomal DNA internal transcribed spacer analysis supports synonomy of Scedosporium inflatum and Lomentospora prolificans. J Clin Microbiol 1994; 32:2413.
  19. Gueho E, Hoog GS de. Taxonomy of the medical species of Pseudallescheria and Scedosporium. J Mycol Med 1991; 1:3.
  20. Hennebert GL, Desai BG. Lomentospora prolificansa New Hypohomycete from Greenhouse Soil. Mycotaxo 1974; 1:45.
  21. Hennebert GI, Desai BG. Lomentospora prolificans, a new hyphomycete from greenhous soil. Mycotaxon 1974; 1:44.
  22. Summerbell RC, Krajden S, Kane J. Potted plants in hospitals as reservoirs of pathogenic fungi. Mycopathologia 1989; 106:13.
  23. Travis LB, Roberts GD, Wilson WR. Clinical significance of Pseudallescheria boydii: a review of 10 years' experience. Mayo Clin Proc 1985; 60:531.
  24. Berenguer J, Rodríguez-Tudela JL, Richard C, et al. Deep infections caused by Scedosporium prolificans. A report on 16 cases in Spain and a review of the literature. Scedosporium Prolificans Spanish Study Group. Medicine (Baltimore) 1997; 76:256.
  25. Idigoras P, Pérez-Trallero E, Piñeiro L, et al. Disseminated infection and colonization by Scedosporium prolificans: a review of 18 cases, 1990-1999. Clin Infect Dis 2001; 32:E158.
  26. Alvarez M, Lopez Ponga B, Rayon C, et al. Nosocomial outbreak caused by Scedosporium prolificans (inflatum): four fatal cases in leukemic patients. J Clin Microbiol 1995; 33:3290.
  27. Wood GM, McCormack JG, Muir DB, et al. Clinical features of human infection with Scedosporium inflatum. Clin Infect Dis 1992; 14:1027.
  28. Tamm M, Malouf M, Glanville A. Pulmonary scedosporium infection following lung transplantation. Transpl Infect Dis 2001; 3:189.
  29. Husain S, Muñoz P, Forrest G, et al. Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome. Clin Infect Dis 2005; 40:89.
  30. Wilson CM, O'Rourke EJ, McGinnis MR, Salkin IF. Scedosporium inflatum: clinical spectrum of a newly recognized pathogen. J Infect Dis 1990; 161:102.
  31. Revankar SG, Patterson JE, Sutton DA, et al. Disseminated phaeohyphomycosis: review of an emerging mycosis. Clin Infect Dis 2002; 34:467.
  32. del Palacio A, Garau M, Amor E, et al. Case reports. Transient colonization with Scedosporium prolificans. Report of four cases in Madrid. Mycoses 2001; 44:321.
  33. Guerrero A, Torres P, Duran MT, et al. Airborne outbreak of nosocomial Scedosporium prolificans infection. Lancet 2001; 357:1267.
  34. Simarro E, Marín F, Morales A, et al. Fungemia due to Scedosporium prolificans: a description of two cases with fatal outcome. Clin Microbiol Infect 2001; 7:645.
  35. Cooley L, Spelman D, Thursky K, Slavin M. Infection with Scedosporium apiospermum and S. prolificans, Australia. Emerg Infect Dis 2007; 13:1170.
  36. Park BJ, Pappas PG, Wannemuehler KA, et al. Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006. Emerg Infect Dis 2011; 17:1855.
  37. Lamaris GA, Chamilos G, Lewis RE, et al. Scedosporium infection in a tertiary care cancer center: a review of 25 cases from 1989-2006. Clin Infect Dis 2006; 43:1580.
  38. Alastruey-Izquierdo A, Mellado E, Peláez T, et al. Population-based survey of filamentous fungi and antifungal resistance in Spain (FILPOP Study). Antimicrob Agents Chemother 2013; 57:3380.
  39. Slavin M, van Hal S, Sorrell TC, et al. Invasive infections due to filamentous fungi other than Aspergillus: epidemiology and determinants of mortality. Clin Microbiol Infect 2015; 21:490.e1.
  40. Cimon B, Carrère J, Vinatier JF, et al. Clinical significance of Scedosporium apiospermum in patients with cystic fibrosis. Eur J Clin Microbiol Infect Dis 2000; 19:53.
  41. Symoens F, Knoop C, Schrooyen M, et al. Disseminated Scedosporium apiospermum infection in a cystic fibrosis patient after double-lung transplantation. J Heart Lung Transplant 2006; 25:603.
  42. Defontaine A, Zouhair R, Cimon B, et al. Genotyping study of Scedosporium apiospermum isolates from patients with cystic fibrosis. J Clin Microbiol 2002; 40:2108.
  43. Williamson EC, Speers D, Arthur IH, et al. Molecular epidemiology of Scedosporium apiospermum infection determined by PCR amplification of ribosomal intergenic spacer sequences in patients with chronic lung disease. J Clin Microbiol 2001; 39:47.
  44. Schwarz C, Brandt C, Antweiler E, et al. Prospective multicenter German study on pulmonary colonization with Scedosporium /Lomentospora species in cystic fibrosis: Epidemiology and new association factors. PLoS One 2017; 12:e0171485.
  45. Blyth CC, Middleton PG, Harun A, et al. Clinical associations and prevalence of Scedosporium spp. in Australian cystic fibrosis patients: identification of novel risk factors? Med Mycol 2010; 48 Suppl 1:S37.
  46. Zouhair R, Rougeron A, Razafimandimby B, et al. Distribution of the different species of the Pseudallescheria boydii/Scedosporium apiospermum complex in French patients with cystic fibrosis. Med Mycol 2013; 51:603.
  47. Parize P, Boussaud V, Poinsignon V, et al. Clinical outcome of cystic fibrosis patients colonized by Scedosporium species following lung transplantation: A single-center 15-year experience. Transpl Infect Dis 2017; 19.
  48. Johnson LS, Shields RK, Clancy CJ. Epidemiology, clinical manifestations, and outcomes of Scedosporium infections among solid organ transplant recipients. Transpl Infect Dis 2014; 16:578.
  49. Jabado N, Casanova JL, Haddad E, et al. Invasive pulmonary infection due to Scedosporium apiospermum in two children with chronic granulomatous disease. Clin Infect Dis 1998; 27:1437.
  50. Horré R, Jovanić B, Marklein G, et al. Fatal pulmonary scedosporiosis. Mycoses 2003; 46:418.
  51. García-Arata MI, Otero MJ, Zomeño M, et al. Scedosporium apiospermum pneumonia after autologous bone marrow transplantation. Eur J Clin Microbiol Infect Dis 1996; 15:600.
  52. Klopfenstein KJ, Rosselet R, Termuhlen A, Powell D. Successful treatment of Scedosporium pneumonia with voriconazole during AML therapy and bone marrow transplantation. Med Pediatr Oncol 2003; 41:494.
  53. Nomdedéu J, Brunet S, Martino R, et al. Successful treatment of pneumonia due to Scedosporium apiospermum with itraconazole: case report. Clin Infect Dis 1993; 16:731.
  54. Goldberg SL, Geha DJ, Marshall WF, et al. Successful treatment of simultaneous pulmonary Pseudallescheria boydii and Aspergillus terreus infection with oral itraconazole. Clin Infect Dis 1993; 16:803.
  55. Marr KA, Carter RA, Crippa F, et al. Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Clin Infect Dis 2002; 34:909.
  56. Castiglioni B, Sutton DA, Rinaldi MG, et al. Pseudallescheria boydii (Anamorph Scedosporium apiospermum). Infection in solid organ transplant recipients in a tertiary medical center and review of the literature. Medicine (Baltimore) 2002; 81:333.
  57. Raj R, Frost AE. Scedosporium apiospermum fungemia in a lung transplant recipient. Chest 2002; 121:1714.
  58. Patterson TF, Andriole VT, Zervos MJ, et al. The epidemiology of pseudallescheriasis complicating transplantation: nosocomial and community-acquired infection. Mycoses 1990; 33:297.
  59. Perlroth MG, Miller J. Pseudoallescheria boydii pneumonia and empyema: a rare complication of heart transplantation cured with voriconazole. J Heart Lung Transplant 2004; 23:647.
  60. Talbot TR, Hatcher J, Davis SF, et al. Scedosporium apiospermum pneumonia and sternal wound infection in a heart transplant recipient. Transplantation 2002; 74:1645.
  61. Díaz-Valle D, Benitez del Castillo JM, Amor E, et al. Severe keratomycosis secondary to Scedosporium apiospermum. Cornea 2002; 21:516.
  62. Hernández Prats C, Llinares Tello F, Burgos San José A, et al. Voriconazole in fungal keratitis caused by Scedosporium apiospermum. Ann Pharmacother 2004; 38:414.
  63. Nulens E, Eggink C, Rijs AJ, et al. Keratitis caused by Scedosporium apiospermum successfully treated with a cornea transplant and voriconazole. J Clin Microbiol 2003; 41:2261.
  64. Wu Z, Ying H, Yiu S, et al. Fungal keratitis caused by Scedosporium apiospermum: report of two cases and review of treatment. Cornea 2002; 21:519.
  65. del Palacio A, Perez-Blazquez E, Cuétara MS, et al. Keratomycosis due to Scedosporium apiospermum. Mycoses 1991; 34:483.
  66. Larocco A Jr, Barron JB. Endogenous scedosporium apiospermum endophthalmitis. Retina 2005; 25:1090.
  67. Caya JG, Farmer SG, Williams GA, et al. Bilateral Pseudallescheria boydii endophthalmitis in an immunocompromised patient. Wis Med J 1988; 87:11.
  68. Figueroa MS, Fortun J, Clement A, De Arévalo BF. Endogenous endophthalmitis caused by Scedosporium apiospermum treated with voriconazole. Retina 2004; 24:319.
  69. Leck A, Matheson M, Tuft S, et al. Scedosporium apiospermum keratomycosis with secondary endophthalmitis. Eye (Lond) 2003; 17:841.
  70. Pfeifer JD, Grand MG, Thomas MA, et al. Endogenous Pseudallescheria boydii endophthalmitis. Clinicopathologic findings in two cases. Arch Ophthalmol 1991; 109:1714.
  71. Luu KK, Scott IU, Miller D, Davis JL. Endogenous Pseudallescheria boydii endophthalmitis in a patient with ring-enhancing brain lesions. Ophthalmic Surg Lasers 2001; 32:325.
  72. Lopez FA, Crowley RS, Wastila L, et al. Scedosporium apiospermum (Pseudallescheria boydii) infection in a heart transplant recipient: a case of mistaken identity. J Heart Lung Transplant 1998; 17:321.
  73. Fortún J, Martín-Dávila P, Sánchez MA, et al. Voriconazole in the treatment of invasive mold infections in transplant recipients. Eur J Clin Microbiol Infect Dis 2003; 22:408.
  74. McKelvie PA, Wong EY, Chow LP, Hall AJ. Scedosporium endophthalmitis: two fatal disseminated cases of Scedosporium infection presenting with endophthalmitis. Clin Exp Ophthalmol 2001; 29:330.
  75. Horré R, Feil E, Stangel AP, et al. [Scedosporiosis of the brain with fatal outcome after traumatizatio of the foot. case report]. Mycoses 2000; 43 Suppl 2:33.
  76. Rüchel R, Wilichowski E. Cerebral Pseudallescheria mycosis after near-drowning. Mycoses 1995; 38:473.
  77. Safdar A, Papadopoulos EB, Young JW. Breakthrough Scedosporium apiospermum (Pseudallescheria boydii) brain abscess during therapy for invasive pulmonary aspergillosis following high-risk allogeneic hematopoietic stem cell transplantation. Scedosporiasis and recent advances in antifungal therapy. Transpl Infect Dis 2002; 4:212.
  78. Montero A, Cohen JE, Fernández MA, et al. Cerebral pseudallescheriasis due to Pseudallescheria boydii as the first manifestation of AIDS. Clin Infect Dis 1998; 26:1476.
  79. Mursch K, Trnovec S, Ratz H, et al. Successful treatment of multiple Pseudallescheria boydii brain abscesses and ventriculitis/ependymitis in a 2-year-old child after a near-drowning episode. Childs Nerv Syst 2006; 22:189.
  80. Chakraborty A, Workman MR, Bullock PR. Scedosporium apiospermum brain abscess treated with surgery and voriconazole. Case report. J Neurosurg 2005; 103:83.
  81. Kowacs PA, Soares Silvado CE, Monteiro de Almeida S, et al. Infection of the CNS by Scedosporium apiospermum after near drowning. Report of a fatal case and analysis of its confounding factors. J Clin Pathol 2004; 57:205.
  82. Dworzack DL, Clark RB, Borkowski WJ Jr, et al. Pseudallescheria boydii brain abscess: association with near-drowning and efficacy of high-dose, prolonged miconazole therapy in patients with multiple abscesses. Medicine (Baltimore) 1989; 68:218.
  83. Mellinghoff IK, Winston DJ, Mukwaya G, Schiller GJ. Treatment of Scedosporium apiospermum brain abscesses with posaconazole. Clin Infect Dis 2002; 34:1648.
  84. Baddley JW, Stroud TP, Salzman D, Pappas PG. Invasive mold infections in allogeneic bone marrow transplant recipients. Clin Infect Dis 2001; 32:1319.
  85. Montejo M, Muñiz ML, Zárraga S, et al. Case Reports. Infection due to Scedosporium apiospermum in renal transplant recipients: a report of two cases and literature review of central nervous system and cutaneous infections by Pseudallescheria boydii/Sc. apiospermum. Mycoses 2002; 45:418.
  86. Nesky MA, McDougal EC, Peacock Jr JE. Pseudallescheria boydii brain abscess successfully treated with voriconazole and surgical drainage: case report and literature review of central nervous system pseudallescheriasis. Clin Infect Dis 2000; 31:673.
  87. Canet JJ, Pagerols X, Sánchez C, et al. Lymphocutaneous syndrome due to Scedosporium apiospermum. Clin Microbiol Infect 2001; 7:648.
  88. Karaarslan A, Arikan S, Karaarslan F, Cetin ES. Skin infection caused by Scedosporium apiospermum. Mycoses 2003; 46:524.
  89. Girmenia C, Luzi G, Monaco M, Martino P. Use of voriconazole in treatment of Scedosporium apiospermum infection: case report. J Clin Microbiol 1998; 36:1436.
  90. Schaenman JM, DiGiulio DB, Mirels LF, et al. Scedosporium apiospermum soft tissue infection successfully treated with voriconazole: potential pitfalls in the transition from intravenous to oral therapy. J Clin Microbiol 2005; 43:973.
  91. Piper JP, Golden J, Brown D, Broestler J. Successful treatment of Scedosporium apiospermum suppurative arthritis with itraconazole. Pediatr Infect Dis J 1990; 9:674.
  92. German JW, Kellie SM, Pai MP, Turner PT. Treatment of a chronic Scedosporium apiospermum vertebral osteomyelitis. Case report. Neurosurg Focus 2004; 17:E9.
  93. O'Doherty M, Hannan M, Fulcher T. Voriconazole in the treatment of fungal osteomyelitis of the orbit in the immunocompromised host. Orbit 2005; 24:285.
  94. Levine NB, Kurokawa R, Fichtenbaum CJ, et al. An immunocompetent patient with primary Scedosporium apiospermum vertebral osteomyelitis. J Spinal Disord Tech 2002; 15:425.
  95. Gatto J, Paterson D, Davis L, et al. Vertebral osteomyelitis due to Pseudallescheria boydii. Pathology 1997; 29:238.
  96. Hung LH, Norwood LA. Osteomyelitis due to Pseudallescheria boydii. South Med J 1993; 86:231.
  97. Kanafani ZA, Comair Y, Kanj SS. Pseudallescheria boydii cranial osteomyelitis and subdural empyema successfully treated with voriconazole: a case report and literature review. Eur J Clin Microbiol Infect Dis 2004; 23:836.
  98. Lonser RR, Brodke DS, Dailey AT. Vertebral osteomyelitis secondary to Pseudallescheria boydii. J Spinal Disord 2001; 14:361.
  99. Sopta J, Atanacković M, Raspopović V, et al. [Pseudoallescheria boydii (Scedosporium apiospermum), cause of mycotic granulomatous osteomyelitis--case diagnosis]. Srp Arh Celok Lek 2005; 133:366.
  100. Dellestable F, Kures L, Mainard D, et al. Fungal arthritis due to Pseudallescheria boydii (Scedosporium apiospermum). J Rheumatol 1994; 21:766.
  101. Fernández-Guerrero ML, Ruiz Barnés P, Alés JM. Postcraniotomy mycetoma of the scalp and osteomyelitis due to Pseudallescheria boydii. J Infect Dis 1987; 156:855.
  102. Taj-Aldeen SJ, Rammaert B, Gamaletsou M, et al. Osteoarticular Infections Caused by Non-Aspergillus Filamentous Fungi in Adult and Pediatric Patients: A Systematic Review. Medicine (Baltimore) 2015; 94:e2078.
  103. Sampaio FM, Wanke B, Freitas DF, et al. Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. PLoS Negl Trop Dis 2017; 11:e0005301.
  104. Muñoz P, Marín M, Tornero P, et al. Successful outcome of Scedosporium apiospermum disseminated infection treated with voriconazole in a patient receiving corticosteroid therapy. Clin Infect Dis 2000; 31:1499.
  105. Riddell J 4th, Chenoweth CE, Kauffman CA. Disseminated Scedosporium apiospermum infection in a previously healthy woman with HELLP syndrome. Mycoses 2004; 47:442.
  106. Eckburg PB, Zolopa AR, Montoya JG. Invasive fungal sinusitis due to Scedosporium apiospermum in a patient with AIDS. Clin Infect Dis 1999; 29:212.
  107. Machado CM, Martins MA, Heins-Vaccari EM, et al. Scedosporium apiospermum sinusitis after bone marrow transplantation: report of a case. Rev Inst Med Trop Sao Paulo 1998; 40:321.
  108. Kiraz N, Gülbas Z, Akgün Y, Uzun O. Lymphadenitis caused by Scedosporium apiospermum in an immunocompetent patient. Clin Infect Dis 2001; 32:E59.
  109. Ben Hamida M, Bedrossian J, Pruna A, et al. Fungal mycotic aneurysms and visceral infection due to Scedosporium apiospermum in a kidney transplant patient. Transplant Proc 1993; 25:2290.
  110. Clement ME, Maziarz EK, Schroder JN, et al. Scedosporium apiosermum infection of the "Native" valve: Fungal endocarditis in an orthotopic heart transplant recipient. Med Mycol Case Rep 2015; 9:34.
  111. Rodriguez-Tudela JL, Berenguer J, Guarro J, et al. Epidemiology and outcome of Scedosporium prolificans infection, a review of 162 cases. Med Mycol 2009; 47:359.
  112. Arthur S, Steed LL, Apple DJ, et al. Scedosporium prolificans keratouveitis in association with a contact lens retained intraocularly over a long term. J Clin Microbiol 2001; 39:4579.
  113. Sullivan LJ, Snibson G, Joseph C, Taylor HR. Scedosporium prolificans sclerokeratitis. Aust N Z J Ophthalmol 1994; 22:207.
  114. Kumar B, Crawford GJ, Morlet GC. Scedosporium prolificans corneoscleritis: a successful outcome. Aust N Z J Ophthalmol 1997; 25:169.
  115. Moriarty AP, Crawford GJ, McAllister IL, Constable IJ. Fungal corneoscleritis complicating beta-irradiation-induced scleral necrosis following pterygium excision. Eye (Lond) 1993; 7 ( Pt 4):525.
  116. Taylor A, Wiffen SJ, Kennedy CJ. Post-traumatic Scedosporium inflatum endophthalmitis. Clin Exp Ophthalmol 2002; 30:47.
  117. Vagefi MR, Kim ET, Alvarado RG, et al. Bilateral endogenous Scedosporium prolificans endophthalmitis after lung transplantation. Am J Ophthalmol 2005; 139:370.
  118. Maertens J, Lagrou K, Deweerdt H, et al. Disseminated infection by Scedosporium prolificans: an emerging fatality among haematology patients. Case report and review. Ann Hematol 2000; 79:340.
  119. Lentine KL, Brennan DC, Schnitzler MA. Incidence and predictors of myocardial infarction after kidney transplantation. J Am Soc Nephrol 2005; 16:496.
  120. Nenoff P, Gütz U, Tintelnot K, et al. Disseminated mycosis due to Scedosporium prolificans in an AIDS patient with Burkitt lymphoma. Mycoses 1996; 39:461.
  121. Madrigal V, Alonso J, Bureo E, et al. Fatal meningoencephalitis caused by Scedosporium inflatum (Scedosporium prolificans) in a child with lymphoblastic leukemia. Eur J Clin Microbiol Infect Dis 1995; 14:601.
  122. Salesa R, Burgos A, Ondiviela R, et al. Fatal disseminated infection by Scedosporium inflatum after bone marrow transplantation. Scand J Infect Dis 1993; 25:389.
  123. Uno K, Kasahara K, Kutsuna S, et al. Infective endocarditis and meningitis due to Scedosporium prolificans in a renal transplant recipient. J Infect Chemother 2014; 20:131.
  124. Tamaki M, Nozaki K, Onishi M, et al. Fungal meningitis caused by Lomentospora prolificans after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis 2016; 18:601.
  125. Steinbach WJ, Schell WA, Miller JL, Perfect JR. Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide. J Clin Microbiol 2003; 41:3981.
  126. Gosbell IB, Toumasatos V, Yong J, et al. Cure of orthopaedic infection with Scedosporium prolificans, using voriconazole plus terbinafine, without the need for radical surgery. Mycoses 2003; 46:233.
  127. Pickles RW, Pacey DE, Muir DB, Merrell WH. Experience with infection by Scedosporium prolificans including apparent cure with fluconazole therapy. J Infect 1996; 33:193.
  128. Kelly M, Stevens R, Konecny P. Lomentospora prolificans endocarditis--case report and literature review. BMC Infect Dis 2016; 16:36.
  129. Wakabayashi Y, Okugawa S, Tatsuno K, et al. Scedosporium prolificans Endocarditis: Case Report and Literature Review. Intern Med 2016; 55:79.
  130. Ochi Y, Hiramoto N, Takegawa H, et al. Infective endocarditis caused by Scedosporium prolificans infection in a patient with acute myeloid leukemia undergoing induction chemotherapy. Int J Hematol 2015; 101:620.
  131. Fernandez Guerrero ML, Askari E, Prieto E, et al. Emerging infectious endocarditis due to Scedosporium prolificans: a model of therapeutic complexity. Eur J Clin Microbiol Infect Dis 2011; 30:1321.
  132. de Batlle J, Motjé M, Balanzà R, et al. Disseminated infection caused by Scedosporium prolificans in a patient with acute multilineal leukemia. J Clin Microbiol 2000; 38:1694.
  133. Howden BP, Slavin MA, Schwarer AP, Mijch AM. Successful control of disseminated Scedosporium prolificans infection with a combination of voriconazole and terbinafine. Eur J Clin Microbiol Infect Dis 2003; 22:111.
  134. Marin J, Sanz MA, Sanz GF, et al. Disseminated Scedosporium inflatum infection in a patient with acute myeloblastic leukemia. Eur J Clin Microbiol Infect Dis 1991; 10:759.
  135. Rabodonirina M, Paulus S, Thevenet F, et al. Disseminated Scedosporium prolificans (S. inflatum) infection after single-lung transplantation. Clin Infect Dis 1994; 19:138.
  136. Bouza E, Muñoz P, Vega L, et al. Clinical resolution of Scedosporium prolificans fungemia associated with reversal of neutropenia following administration of granulocyte colony-stimulating factor. Clin Infect Dis 1996; 23:192.
  137. Spielberger RT, Tegtmeier BR, O'Donnell MR, Ito JI. Fatal Scedosporium prolificans (S. inflatum) fungemia following allogeneic bone marrow transplantation: report of a case in the United States. Clin Infect Dis 1995; 21:1067.
  138. De Pauw B, Walsh TJ, Donnelly JP, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 2008; 46:1813.
  139. Tarrand JJ, Lichterfeld M, Warraich I, et al. Diagnosis of invasive septate mold infections. A correlation of microbiological culture and histologic or cytologic examination. Am J Clin Pathol 2003; 119:854.
  140. Pryce TM, Palladino S, Price DM, et al. Rapid identification of fungal pathogens in BacT/ALERT, BACTEC, and BBL MGIT media using polymerase chain reaction and DNA sequencing of the internal transcribed spacer regions. Diagn Microbiol Infect Dis 2006; 54:289.
  141. Lionakis MS, Bodey GP, Tarrand JJ, et al. The significance of blood cultures positive for emerging saprophytic moulds in cancer patients. Clin Microbiol Infect 2004; 10:922.
  142. de Aguirre L, Hurst SF, Choi JS, et al. Rapid differentiation of Aspergillus species from other medically important opportunistic molds and yeasts by PCR-enzyme immunoassay. J Clin Microbiol 2004; 42:3495.
  143. Ruiz-Díez B, Martín-Díez F, Rodríguez-Tudela JL, et al. Use of random amplification of polymorphic DNA (RAPD) and PCR-fingerprinting for genotyping a Scedosporium prolificans (inflatum) outbreak in four leukemic patients. Curr Microbiol 1997; 35:186.
  144. Harun A, Blyth CC, Gilgado F, et al. Development and validation of a multiplex PCR for detection of Scedosporium spp. in respiratory tract specimens from patients with cystic fibrosis. J Clin Microbiol 2011; 49:1508.
  145. Lu Q, Gerrits van den Ende AH, Bakkers JM, et al. Identification of Pseudallescheria and Scedosporium species by three molecular methods. J Clin Microbiol 2011; 49:960.
  146. Steinmann J, Schmidt D, Buer J, Rath PM. Discrimination of Scedosporium prolificans against Pseudallescheria boydii and Scedosporium apiospermum by semiautomated repetitive sequence-based PCR. Med Mycol 2011; 49:475.
  147. Castelli MV, Buitrago MJ, Bernal-Martinez L, et al. Development and validation of a quantitative PCR assay for diagnosis of scedosporiosis. J Clin Microbiol 2008; 46:3412.
  148. Odabasi Z, Paetznick VL, Rodriguez JR, et al. Differences in beta-glucan levels in culture supernatants of a variety of fungi. Med Mycol 2006; 44:267.
  149. Odabasi Z, Mattiuzzi G, Estey E, et al. Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome. Clin Infect Dis 2004; 39:199.
  150. Ostrosky-Zeichner L, Alexander BD, Kett DH, et al. Multicenter clinical evaluation of the (1-->3) beta-D-glucan assay as an aid to diagnosis of fungal infections in humans. Clin Infect Dis 2005; 41:654.
  151. Pazos C, Pontón J, Del Palacio A. Contribution of (1->3)-beta-D-glucan chromogenic assay to diagnosis and therapeutic monitoring of invasive aspergillosis in neutropenic adult patients: a comparison with serial screening for circulating galactomannan. J Clin Microbiol 2005; 43:299.
  152. Yoshida M, Obayashi T, Iwama A, et al. Detection of plasma (1 --> 3)-beta-D-glucan in patients with Fusarium, Trichosporon, Saccharomyces and Acremonium fungaemias. J Med Vet Mycol 1997; 35:371.
  153. Ziesing S, Suerbaum S, Sedlacek L. Fungal epidemiology and diversity in cystic fibrosis patients over a 5-year period in a national reference center. Med Mycol 2016; 54:781.
  154. Bernhard M, Zautner AE, Steinmann J, et al. Towards proteomic species barcoding of fungi - An example using Scedosporium/Pseudallescheria complex isolates. Fungal Biol 2016; 120:162.
  155. Sitterlé E, Giraud S, Leto J, et al. Matrix-assisted laser desorption ionization-time of flight mass spectrometry for fast and accurate identification of Pseudallescheria/Scedosporium species. Clin Microbiol Infect 2014; 20:929.
  156. Sleiman S, Halliday CL, Chapman B, et al. Performance of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Aspergillus, Scedosporium, and Fusarium spp. in the Australian Clinical Setting. J Clin Microbiol 2016; 54:2182.
  157. Liu K, Howell DN, Perfect JR, Schell WA. Morphologic criteria for the preliminary identification of Fusarium, Paecilomyces, and Acremonium species by histopathology. Am J Clin Pathol 1998; 109:45.