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Medline ® Abstract for Reference 17

of 'Epidemiology and pathogenesis of portal vein thrombosis in adults'

17
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High FVIII level is associated with idiopathic portal vein thrombosis in South India.
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Koshy A, Jeyakumari M
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Am J Med. 2007;120(6):552.e9.
 
BACKGROUND: In the majority of the cases of portal vein thrombosis in India, the etiology cannot be determined. A high level of factor VIII (FVIII) is a risk factor for venous thromboembolism.
METHODS: In this study from South India, FVIII was estimated in 32 patients with idiopathic portal vein thrombosis (PVT), 12 healthy controls and 12 disease controls with chronic liver disease.
RESULTS: Eighty-four percent of the patients with portal vein thrombosis (27/32) vs 17% of healthy controls (2/12) had high factor VIII levels (P<.0001). FVIII levels were significantly different between the subset of PVT patients with normal liver function compared with healthy controls (P<.001) and also between the subset of PVT patients with abnormal liver function compared with disease controls (P<.05).
CONCLUSIONS: A high factor VIII level seems to contribute to the development of portal vein thrombosis in India.
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Department of Gastroenterology, Institute of Population Health and Clinical Research, St. John's Medical College Hospital, Bangalore, India. koshyabe@yahoo.com
PMID