Medline ® Abstract for Reference 49
of 'Epidemiology and etiology of osteoporosis in men'
Bone mineral density and androgen levels in elderly males.
Rapado A, Hawkins F, Sobrinho L, Díaz-Curiel M, Galvao-Telles A, Arver S, Melo Gomes J, Mazer N, Garcia e Costa J, Horcajada C, López-Gavilanes E, Mascarenhas M, Papapietro K, López Alvarez MB, Pereira MC, Martinez G, Valverde I, García JJ, Carballal JJ, García I
Calcif Tissue Int. 1999;65(6):417.
To clarify the relationship of sex male hormones and bone in men, we studied in 140 healthy elderly men (aged 55-90 years) the relation between serum levels of androgens and related sex hormones, bone mineral density (BMD) at different sites, and other parameters related to bone metabolism. Our results show a slight decrease of serum-free testosterone with age, with an increase of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in a third of the elderly subjects studied. BMD decreased significantly with age in all regions studied, except in the lumbar spine. We found a positive correlation between body mass index (BMI) and BMD at the lumbar spine and femoral neck (P<0.001). No relationship was found (uni- and multivariate regression analysis) between serum androgens or sex hormone-binding globulin (SHBG) and BMD. We found a positive correlation of vitamin D binding protein (DBP) and osteocalcin with lumbar spine BMD and with BMI, DBP, IGF-1, and PTH with femoral neck BMD. In conclusion, there is a slight decline in free testosterone and BMD in the healthy elderly males. However, sex male hormones are not correlated to the decrease in hip BMD. Other age-related factors must be associated with bone loss in elderly males.
Clínica de Na Sra de la Concepción, Fundación Jiménez Díaz, Madrid, Spain.