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Eosinophilic gastroenteritis

Authors
Calman Prussin, MD
Nirmala Gonsalves, MD
Section Editor
Lawrence S Friedman, MD
Deputy Editor
Shilpa Grover, MD, MPH

INTRODUCTION

Eosinophilic gastroenteritis (EG) belongs to a group of diseases that includes eosinophilic esophagitis, gastritis, enteritis, and colitis, collectively referred to as "eosinophilic gastrointestinal disorders" [1].

This topic will review the clinical manifestations, diagnosis, and management of EG. Eosinophilic esophagitis is discussed in detail separately. (See "Clinical manifestations and diagnosis of eosinophilic esophagitis".)

DEFINITION

Eosinophilic gastroenteritis (EG) is an inflammatory disorder characterized by eosinophilic infiltration of the stomach and duodenum, and, in some cases, the esophagus and colon without any known cause of eosinophilia.

EPIDEMIOLOGY

There are limited data on the prevalence of eosinophilic gastroenteritis (EG). The prevalence of EG in the United States is estimated to be 22 to 28 per 100,000 persons [2]. EG can affect patients of any age, but typically presents in the third through fifth decade and has a peak age of onset in the third decade [3-5]. A slight male predominance has been reported.

PATHOGENESIS

The pathogenesis of eosinophilic gastroenteritis (EG) is not well understood. Several epidemiologic and clinical features suggest an allergic component [3,6,7]. In addition, patients with EG have elevated serum immunoglobulin E (IgE) levels [7-10]. (See 'Clinical manifestations' below and 'Laboratory findings' below.)

                     

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Literature review current through: Nov 2016. | This topic last updated: Thu Aug 21 00:00:00 GMT+00:00 2014.
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References
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