- Nirmala Gonsalves, MD
Nirmala Gonsalves, MD
- Associate Professor of Medicine
- Northwestern University Feinberg School of Medicine
Eosinophilic gastroenteritis (EGE) belongs to a group of diseases that includes eosinophilic esophagitis, gastritis, enteritis, and colitis, collectively referred to as "eosinophilic gastrointestinal disorders" .
This topic will review the clinical manifestations, diagnosis, and management of EGE. Eosinophilic esophagitis is discussed in detail, separately. (See "Clinical manifestations and diagnosis of eosinophilic esophagitis".)
Eosinophilic gastroenteritis (EGE) is an inflammatory disorder characterized by eosinophilic infiltration of the stomach and duodenum, and in some cases, the esophagus and colon without any known cause of eosinophilia.
There are limited data on the prevalence of eosinophilic gastroenteritis (EGE). The prevalence of EGE in the United States is estimated to be 22 to 28 per 100,000 persons . EGE can affect patients of any age, but typically presents in the third through fifth decades and has a peak age of onset in the third decade [3-5]. A slight male predominance has been reported.
The pathogenesis of eosinophilic gastroenteritis (EGE) is not well understood. Multiple epidemiologic and clinical features suggest an allergic component [3,6,7]. In addition, patients with EGE have elevated serum immunoglobulin E (IgE) levels [7-10]. (See 'Clinical manifestations' below and 'Laboratory findings' below.)
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- CLINICAL MANIFESTATIONS
- Mucosal disease
- Muscular layer disease
- Subserosal disease
- LABORATORY FINDINGS
- IMAGING FINDINGS
- - History and physical examination
- - Laboratory evaluation and other testing
- - Endoscopy and biopsy
- - Full-thickness biopsy
- DIFFERENTIAL DIAGNOSIS
- DISEASE COURSE
- lnitial therapy
- - Dietary therapy
- - Glucocorticoids
- Recurrent symptoms
- Other therapies
- SUMMARY AND RECOMMENDATIONS