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Medline ® Abstract for Reference 1

of 'Endoscopic ultrasound in the staging of exocrine pancreatic cancer'

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The epidemiology of pancreatic cancer in the United States: changes below the surface.
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Shaib YH, Davila JA, El-Serag HB
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Aliment Pharmacol Ther. 2006;24(1):87.
 
BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer death in the United States.
AIM: To examine temporal changes in the incidence and survival of patients with pancreatic adenocarcinoma.
METHODS: Using data from nine registries of the Surveillance, Epidemiology and End Results programme, age-adjusted incidence rates per 100 000 and survival rates were calculated for pancreatic cancer between 1977 and 2001.
RESULTS: We identified 58 655 cases of pancreatic cancer. The age-adjusted incidence rate remained stable during the study period (11.3 in 1977-1981 and 10.9 in 1997-2001). Overall, men were 30% more affected than women (age-adjusted incidence rate of 13.0 in men and 9.8 in women). The age-adjusted incidence rates were almost 50% higher among Blacks (16.4) than Whites (10.8) and people of other races (9.8). Over time the proportions of patients with localized disease decreased from 12.3% to 7.4% and those with regional disease increased from 18.6% to 25.8%, while metastatic disease remained stable (52.5% vs. 49.8%). The 1-year relative survival increased from 15.2% in 1977-1981 to 21.6% in 1997-2001.
CONCLUSIONS: The incidence of pancreatic cancer is stable. A shift from localized to regional disease was observed over time. The overall survival remains poor despite important improvements among patients with early stage disease.
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Section of Health Services Research, Michael E. Debakey Veterans Affairs Medical Center, Houston, TX 77030, USA. yshaib@bcm.tmc.edu
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