EUS-guided fine needle aspiration of the liver: indications, yield, and safety based on an international survey of 167 cases

Gastrointest Endosc. 2002 Jun;55(7):859-62. doi: 10.1067/mge.2002.124557.

Abstract

Background: The liver is a common site of metastases for various malignancies. EUS-guided fine needle aspiration (EUS-FNA) of liver masses has only been reported in small series from single centers.

Methods: A retrospective questionnaire was sent by e-mail to 130 EUS-FNA centers around the world regarding indications, complications, and findings of EUS-FNA of the liver.

Results: Twenty-one centers reported 167 cases of EUS-FNA of the liver. A complication was reported in 6 (4%) of 167 cases including the following: death in 1 patient with an occluding biliary stent and biliary sepsis, bleeding (1), fever (2), and pain (2). EUS-FNA diagnosed malignancy in 23 of 26 (89%) cases after nondiagnostic fine needle aspiration under transabdominal US guidance. EUS localized an unrecognized primary tumor in 17 of 33 (52%) cases in which CT had demonstrated only liver metastases. EUS image characteristics were not predictive of malignant versus benign lesions.

Conclusion: EUS-guided FNA of the liver appears to be a safe procedure with a major complication rate of approximately 1%. EUS-FNA should be considered when a liver lesion is poorly accessible to US-, or CT-guided FNA should be considered when US- or CT-guided FNA fail to make a diagnosis, when a liver lesion(s) is detected (de novo) by EUS, and for investigation of possible upper GI primary tumors in the setting of liver metastases.

Publication types

  • Multicenter Study

MeSH terms

  • Attitude of Health Personnel
  • Biopsy, Needle / adverse effects*
  • Endoscopy, Digestive System / adverse effects*
  • Endosonography / adverse effects*
  • Health Care Surveys*
  • Humans
  • International Cooperation*
  • Liver / diagnostic imaging*
  • Liver / pathology*
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / therapy
  • Outcome Assessment, Health Care
  • Reproducibility of Results
  • Retrospective Studies
  • Sensitivity and Specificity