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Katharine Esselen, MD, MBA
Robert L Barbieri, MD
Section Editor
Tommaso Falcone, MD, FRCSC, FACOG
Deputy Editor
Sandy J Falk, MD, FACOG


Endosalpingiosis is the presence of ectopic, cystic glands outside the fallopian tube that are lined with fallopian tube-type ciliated epithelium [1]. Endosalpingiosis may occur in pelvic organs, including ovaries, fallopian tube serosa, uterine serosa, myometrium, or pelvic peritoneum. It may also occur in the bladder or in a retroperitoneal or axillary lymph node [2].

Endosalpingiosis is not well-studied, and the clinical features remain uncertain. It has been reported to be associated with pelvic pain, infertility, pelvic mass, and/or urinary symptoms [3-6]. However, the diagnosis is made only after surgical biopsy. A key challenge regarding this condition is to differentiate it clinically from endometriosis.

Another notable feature of endosalpingiosis is its histologic relationship to pelvic serous neoplasms (eg, lesions of low malignant potential, low-grade pelvic serous carcinoma). However, the role of endosalpingiosis as a risk factor or as part of the pathogenesis of these conditions is unknown.

The pathology, diagnosis, and management of endosalpingiosis will be reviewed here. Topics regarding endometriosis are discussed separately. (See "Endometriosis: Pathogenesis, clinical features, and diagnosis" and "Endometriosis: Treatment of pelvic pain".)


The prevalence of endosalpingiosis is difficult to establish. There are few data regarding this condition. In addition, endosalpingiosis is diagnosed only through surgical biopsy, so it is unknown if there are asymptomatic cases. It appears that in approximately one-third of cases, patient have coexisting endosalpingiosis and endometriosis [7].

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Literature review current through: Nov 2017. | This topic last updated: Feb 09, 2017.
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