- Katharine Esselen, MD, MBA
Katharine Esselen, MD, MBA
- Instructor of Medicine
- Harvard Medical School
- Robert L Barbieri, MD
Robert L Barbieri, MD
- Editor-in-Chief — Obstetrics, Gynecology and Women's Health
- Section Editor — General Gynecology and Female Reproductive Endocrinology
- Kate Macy Ladd Professor of Obstetrics, Gynecology and Reproductive Biology
- Harvard Medical School
Endosalpingiosis is the presence of ectopic, cystic glands outside the fallopian tube that are lined with fallopian tube-type ciliated epithelium . Endosalpingiosis may occur in pelvic organs, including ovaries, fallopian tube serosa, uterine serosa, myometrium, or pelvic peritoneum. It may also occur in the bladder or in a retroperitoneal or axillary lymph node .
Endosalpingiosis is not well-studied, and the clinical features remain uncertain. It has been reported to be associated with pelvic pain, infertility, pelvic mass, and/or urinary symptoms [3-6]. However, the diagnosis is made only after surgical biopsy. A key challenge regarding this condition is to differentiate it clinically from endometriosis.
Another notable feature of endosalpingiosis is its histologic relationship to pelvic serous neoplasms (eg, lesions of low malignant potential, low-grade pelvic serous carcinoma). However, the role of endosalpingiosis as a risk factor or as part of the pathogenesis of these conditions is unknown.
The pathology, diagnosis, and management of endosalpingiosis will be reviewed here. Topics regarding endometriosis are discussed separately. (See "Endometriosis: Pathogenesis, clinical features, and diagnosis" and "Endometriosis: Treatment of pelvic pain".)
The prevalence of endosalpingiosis is difficult to establish. There are few data regarding this condition. In addition, endosalpingiosis is diagnosed only through surgical biopsy, so it is unknown if there are asymptomatic cases. It appears that in approximately one-third of cases, patient have coexisting endosalpingiosis and endometriosis .
- Batt RE, Yeh J. Müllerianosis: four developmental (embryonic) mullerian diseases. Reprod Sci 2013; 20:1030.
- Rajarubendra N, Leang Y, Monsour M. Mullerianosis of the urinary bladder. ANZ J Surg 2015; 85:292.
- Laufer MR, Heerema AE, Parsons KE, Barbieri RL. Endosalpingiosis: clinical presentation and follow-up. Gynecol Obstet Invest 1998; 46:195.
- Keltz MD, Kliman HJ, Arici AM, Olive DL. Endosalpingiosis found at laparoscopy for chronic pelvic pain. Fertil Steril 1995; 64:482.
- Ong N, Maher P, Pyman J, et al. Endosalpingiosis, an unrecognized condition: report and literature review. Gynecol Surg 2004; 1:11.
- Prentice L, Stewart A, Mohiuddin S, Johnson NP. What is endosalpingiosis? Fertil Steril 2012; 98:942.
- Esselen KM, Terry KL, Samuel A, et al. Endosalpingiosis: More than just an incidental finding at the time of gynecologic surgery? Gynecol Oncol 2016; 142:255.
- Esselen KM, Ng SK, Hua Y, et al. Endosalpingiosis as it relates to tubal, ovarian and serous neoplastic tissues: an immunohistochemical study of tubal and Müllerian antigens. Gynecol Oncol 2014; 132:316.
- Baker PM, Clement PB, Young RH. Selected topics in peritoneal pathology. Int J Gynecol Pathol 2014; 33:393.
- Gruessner C, Gruessner A, Glaser K, et al. Biomarkers and endosalpingiosis in the ovarian and tubal microenvironment of women at high-risk for pelvic serous carcinoma. Am J Cancer Res 2014; 4:61.
- Heinig J, Gottschalk I, Cirkel U, Diallo R. Endosalpingiosis-an underestimated cause of chronic pelvic pain or an accidental finding? A retrospective study of 16 cases. Eur J Obstet Gynecol Reprod Biol 2002; 103:75.
- Edmondson JD, Vogeley KJ, Howell JD, et al. Endosalpingiosis of bladder. J Urol 2002; 167:1401.
- Maniar KP, Kalir TL, Palese MA, Unger PD. Endosalpingiosis of the urinary bladder: a case of probable implantative origin with characterization of benign Fallopian tube immunohistochemistry. Int J Surg Pathol 2010; 18:381.
- Oida T, Otoshi T, Kobayashi K, et al. [Endocervicosis/endosalpingiosis of the bladder: a case report]. Hinyokika Kiyo 2013; 59:175.
- Olivia Vella JE, Nair N, Ferryman SR, et al. Müllerianosis of the urinary bladder. Int J Surg Pathol 2011; 19:548.
- Clement PB, Young RH. Florid cystic endosalpingiosis with tumor-like manifestations: a report of four cases including the first reported cases of transmural endosalpingiosis of the uterus. Am J Surg Pathol 1999; 23:166.
- Mincik I, Mytnik M, Straka L, et al. Inflammatory pseudotumour of urinary bladder - a rare cause of massive macroscopic haematuria. Bratisl Lek Listy 2013; 114:495.
- Smith C, Sabet L, Izawa JI. Management of endosalpingiosis of urinary bladder. Urology 2004; 64:1031.
- Young RH, Clement PB. Müllerianosis of the urinary bladder. Mod Pathol 1996; 9:731.
- Cheung KW, Cheung VY. Coexisting endosalpingiosis and subserous adenomyosis. J Minim Invasive Gynecol 2015; 22:315.
- Wong WS, Lee ET. Cystic Endosalpingiosis or Multicystic Mesothelioma? J Minim Invasive Gynecol 2016; 23:286.
- Cheung KW, Cheung VY. Response: Cystic Endosalpingiosis or Multicystic Mesothelioma? J Minim Invasive Gynecol 2016; 23:287.