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Endometrial carcinoma: Histopathology and pathogenesis

Margaret M Steinhoff, MD
Section Editors
Barbara Goff, MD
Rochelle L Garcia, MD
Don S Dizon, MD, FACP
Deputy Editor
Sandy J Falk, MD, FACOG


Carcinoma of the endometrium (the lining of the uterus) is the most common gynecologic cancer in developed countries and the second most common in developing countries (cervical carcinoma is the most common in low-resource countries). (See "Endometrial carcinoma: Epidemiology and risk factors", section on 'Epidemiology'.)

There are several histologic types of endometrial carcinoma (EC). Endometrioid histology is the most common, and this typically presents at an early stage with abnormal uterine bleeding, and is most common in postmenopausal women. Other histologic types may have more aggressive clinical behavior.

The histopathology and pathogenesis of EC are reviewed here. Related topics are discussed in detail separately, including:

Overview (see "Overview of endometrial carcinoma")

Epidemiology and risk factors (see "Endometrial carcinoma: Epidemiology and risk factors")

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Literature review current through: Nov 2017. | This topic last updated: May 18, 2017.
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