Endometrial carcinoma: Histopathology and pathogenesis
- Margaret M Steinhoff, MD
Margaret M Steinhoff, MD
- Professor of Pathology and Laboratory Medicine
- The Warren Alpert Medical School of Brown University
- Section Editors
- Barbara Goff, MD
Barbara Goff, MD
- Section Editor — Gynecologic Oncology
- Professor of Gynecologic Oncology
- University of Washington
- Rochelle L Garcia, MD
Rochelle L Garcia, MD
- Section Editor — Obstetric and Gynecologic Pathology
- Professor of Pathology
- Adjunct Professor of Obstetrics & Gynecology
- University of Washington Medical Center
- Don S Dizon, MD, FACP
Don S Dizon, MD, FACP
- Section Editor – Gynecologic Oncology
- Clinical Co-Director, Gynecologic Oncology
- Founder and Director, The Oncology Sexual Health Clinic
- Massachusetts General Hospital Cancer Center
- Associate Professor of Medicine
- Harvard Medical School
Carcinoma of the endometrium (the lining of the uterus) is the most common gynecologic cancer in developed countries and the second most common in developing countries (cervical carcinoma is the most common in low-resource countries). (See "Endometrial carcinoma: Epidemiology and risk factors", section on 'Epidemiology'.)
There are several histologic types of endometrial carcinoma (EC). Endometrioid histology is the most common, and this typically presents at an early stage with abnormal uterine bleeding, and is most common in postmenopausal women. Other histologic types may have more aggressive clinical behavior.
The histopathology and pathogenesis of EC are reviewed here. Related topics are discussed in detail separately, including:
●Overview (see "Overview of endometrial carcinoma")
●Epidemiology and risk factors (see "Endometrial carcinoma: Epidemiology and risk factors")
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- GROSS PATHOLOGY
- Endometrioid carcinoma
- Mucinous carcinoma
- Serous carcinoma
- Clear cell carcinoma
- Mixed cell tumors
- Carcinosarcoma (malignant mixed müllerian tumor)
- Rare subtypes
- PATHOGENESIS AND GENETICS
- Endometrioid carcinomas (type 1)
- Nonendometrioid carcinomas (type 2)
- Genomic subtypes
- Hereditary cancer syndromes
- - Lynch syndrome
- - Cowden syndrome