Patient education: Endometrial cancer diagnosis and staging (Beyond the Basics)
- Lee-may Chen, MD
Lee-may Chen, MD
- Professor of Obstetrics, Gynecology, & Reproductive Sciences
- Division of Gynecologic Oncology
- UCSF Helen Diller Family Comprehensive Cancer Center
- Jonathan S Berek, MD, MMS
Jonathan S Berek, MD, MMS
- Laurie Kraus Lacob Professor
- Stanford University School of Medicine
- Fellow, Stanford Distinguished Careers Institute
- Director, Stanford Women's Cancer Center
- Senior Scientific Advisor, Stanford Cancer Institute
- Section Editor
- Barbara Goff, MD
Barbara Goff, MD
- Section Editor — Gynecologic Oncology
- Professor of Gynecologic Oncology
- University of Washington
- Deputy Editors
- Sadhna R Vora, MD
Sadhna R Vora, MD
- Deputy Editor — Oncology
- Instructor in Medicine
- Harvard Medical School
- Sandy J Falk, MD, FACOG
Sandy J Falk, MD, FACOG
- Director, Editorial Relations — UpToDate
- Deputy Editor — Obstetrics, Gynecology and Women's Health
- Instructor of Obstetrics, Gynecology and Reproductive Biology, Part-time
- Harvard Medical School
Endometrial cancer is a type of uterine cancer that involves the lining of the uterus (the endometrium). In the United States, endometrial cancer is the most common cancer of the female reproductive system. Fortunately, most women are diagnosed at an early stage (before the cancer has spread outside the uterus), when the disease can usually be cured with surgery alone. Endometrial cancer can occur in a woman of any age, although it is much more common after menopause.
This article discusses the risk factors, symptoms, and diagnosis of the most common type of endometrial cancer, called endometrioid endometrial cancer. A separate article discusses the treatment of the endometrioid type of endometrial cancer. (See "Patient education: Endometrial cancer treatment after surgery (Beyond the Basics)".)
More detailed information about endometrial cancer is available by subscription. (See "Endometrial carcinoma: Epidemiology and risk factors" and "Endometrial carcinoma: Pretreatment evaluation, staging, and surgical treatment".)
To understand how endometrial cancer develops, it is helpful to understand the structure of the uterus. The uterus is a pear-shaped organ located between the bladder and the rectum. The cervix connects the uterus to the vagina. The inside of the uterus has two layers. The thin inner layer is called the endometrium. The thick outer layer is composed of muscle and is called the myometrium (myo = muscle) (figure 1).
In women who menstruate, the endometrium thickens every month in preparation for pregnancy. If the woman does not become pregnant, the endometrial lining is shed during the menstrual period. After menopause, when menstrual periods stop, the endometrial lining normally stops growing and shedding. In women who have endometrial cancer, the uterine lining develops abnormal cells.
ENDOMETRIAL CANCER SYMPTOMS
The most common sign of endometrial cancer is abnormal vaginal bleeding.
●In a woman who is still having menstrual periods, abnormal bleeding is defined as bleeding between menstrual periods or heavy menstrual bleeding. (See "Patient education: Abnormal uterine bleeding (Beyond the Basics)".)
●In a postmenopausal woman, any vaginal bleeding is considered abnormal, even if it is only one drop of blood. This is especially true in women who are not taking postmenopausal hormone therapy.
Women who take postmenopausal hormone therapy often have some vaginal bleeding in the first few months of treatment. However, if you are taking postmenopausal hormone therapy and you have bleeding, you should check with your doctor or nurse.
ENDOMETRIAL CANCER DIAGNOSIS AND STAGING
Your doctor or nurse might recommend testing for endometrial cancer if you have abnormal bleeding. The most commonly used tests include:
●A test that is done in the office, called endometrial biopsy.
●A test that is done as a day surgery, called hysteroscopy with dilation and curettage. (See "Patient education: Dilation and curettage (D and C) (Beyond the Basics)".)
These tests take a sample of tissue from the lining of the uterus, called the endometrium. A doctor will examine the tissue with a microscope to see if there are signs of cancer.
Tumor staging — Once endometrial cancer is diagnosed, the next step is to determine its stage. Staging is a system used to describe the spread of a cancer. Endometrial cancer's stage is based on:
●How deeply the cancer has invaded the muscle wall of the uterus
●Whether there are signs that the cancer has spread to other organs on a physical exam, MRI of the abdomen and pelvis, chest X-ray, or other imaging tests
Endometrial cancer stages range from stage I (cancer has not invaded beyond the lining of the uterus) to stage IV (the cancer has spread to distant organs, such as the liver). In general, lower stage cancers are less aggressive and require less treatment than do higher stage cancers.
Surgery — Surgery is usually done to determine how deeply the cancer has invaded the muscle wall of the uterus. At the same time, the cancer can be treated by removing the uterus, ovaries, and fallopian tubes. Surgery is done in an operating room with general anesthesia, and most women stay in the hospital for several days after the surgery.
Surgery can be done by laparoscopy (through small skin incisions in the abdomen and using a camera), if this type of surgery is possible, or through a larger skin incision in the abdomen. This is called a laparotomy. The choice between laparotomy and laparoscopy depends on your situation and you and your surgeon's preferences.
During the surgery, the following procedures are performed:
●The organs are examined within the pelvis and abdomen for signs of cancer.
●The uterus and ovaries are removed (called total hysterectomy and bilateral salpingo-oophorectomy). This procedure is described in detail in a separate article. (See "Patient education: Abdominal hysterectomy (Beyond the Basics)".)
●Fluid from the abdomen and any abnormal tissue in the pelvis or abdomen are evaluated to determine whether the cancer has spread outside of the uterus
●The lymph nodes surrounding the uterus are examined. One of the first places that endometrial cancer spreads to is the lymph nodes. Swelling of the legs (lymphedema) affects approximately 5 to 40 percent of women with endometrial cancer following removal of lymph nodes.
If surgery is not possible — If surgery is too risky, such as in elderly women and women with serious medical problems, radiation therapy alone may be recommended.
FACTORS THAT GUIDE TREATMENT OF ENDOMETRIAL CANCER
The treatment of endometrial cancer depends on how likely it is that the cancer will come back after treatment. This risk is based on:
●The stage of the cancer, which is based on what is found during surgery (see 'Tumor staging' above).
●How aggressive the tumor appears (called the tumor grade) when the tissue is examined under a microscope. High-grade tumors are usually faster growing and more likely to spread than low-grade tumors.
●What type of cells make up the tumor (called cell histology). Some cell types have a higher risk of coming back after treatment.
Depending on these characteristics, the cancer is said to have a low, intermediate, or high risk of coming back after surgery. These designations are used to decide which treatments, if any, are needed after surgery to decrease the risk of the cancer coming back.
Endometrial cancer treatment is discussed in a separate article. (See "Patient education: Endometrial cancer treatment after surgery (Beyond the Basics)".)
ENDOMETRIAL CANCER AND RISK OF OTHER CANCERS
Some individuals with endometrial cancer are at risk for having Lynch syndrome, a genetic disorder that predisposes towards various types of cancers, including endometrial, ovarian, and colorectal cancer. Patients who are diagnosed with endometrial cancer should discuss with their clinician about whether they should be tested for Lynch syndrome. Patients whose tumors display certain high-risk microscopic features, as well as those who developed endometrial cancer prior to age 50 years, and those with a concerning personal or family history of cancer should be referred for genetic counseling and testing for Lynch syndrome. Patients who are found to have Lynch syndrome are screened for Lynch-associated cancers on a routine basis.
PREGNANCY AND ENDOMETRIAL CANCER
Although cancer is more common in postmenopausal women, it can develop in younger women. A woman with endometrial cancer who would like to have a child in the future should discuss treatment options with her doctor. (See "Patient education: Endometrial cancer treatment after surgery (Beyond the Basics)", section on 'Endometrial cancer in the young woman'.)
WHERE TO GET MORE INFORMATION
Your healthcare provider is the best source of information for questions and concerns related to your medical problem.
This article will be updated as needed on our web site (www.uptodate.com/patients). Related topics for patients, as well as selected articles written for healthcare professionals, are also available. Some of the most relevant are listed below.
Patient level information — UpToDate offers two types of patient education materials.
The Basics — The Basics patient education pieces answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials.
Beyond the Basics — Beyond the Basics patient education pieces are longer, more sophisticated, and more detailed. These articles are best for patients who want in-depth information and are comfortable with some medical jargon.
Patient education: Endometrial cancer treatment after surgery (Beyond the Basics)
Patient education: Abnormal uterine bleeding (Beyond the Basics)
Patient education: Dilation and curettage (D and C) (Beyond the Basics)
Patient education: Abdominal hysterectomy (Beyond the Basics)
Professional level information — Professional level articles are designed to keep doctors and other health professionals up-to-date on the latest medical findings. These articles are thorough, long, and complex, and they contain multiple references to the research on which they are based. Professional level articles are best for people who are comfortable with a lot of medical terminology and who want to read the same materials their doctors are reading.
Endometrial carcinoma: Epidemiology and risk factors
Endometrial carcinoma: Pretreatment evaluation, staging, and surgical treatment
Classification and diagnosis of endometrial hyperplasia
Evaluation of the endometrium for malignant or premalignant disease
Endometrial carcinoma: Histopathology and pathogenesis
Treatment of recurrent or metastatic endometrial cancer
Endometrial carcinoma: Type II histology (eg, serous, clear cell, mucinous)
Uterine sarcoma: Classification, clinical manifestations, and diagnosis
Treatment and prognosis of uterine leiomyosarcoma
The following organizations also provide reliable health information.
●American Society of Clinical Oncology
●National Comprehensive Cancer Network
●Gynecologic Oncology Group
●National Cancer Institute
- American College of Obstetricians and Gynecologists. ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer. Obstet Gynecol 2005; 106:413.
- Zerbe MJ, Bristow R, Grumbine FC, Montz FJ. Inability of preoperative computed tomography scans to accurately predict the extent of myometrial invasion and extracorporal spread in endometrial cancer. Gynecol Oncol 2000; 78:67.
- Lee TS, Jung JY, Kim JW, et al. Feasibility of ovarian preservation in patients with early stage endometrial carcinoma. Gynecol Oncol 2007; 104:52.
- Barakat RR, Lev G, Hummer AJ, et al. Twelve-year experience in the management of endometrial cancer: a change in surgical and postoperative radiation approaches. Gynecol Oncol 2007; 105:150.
All topics are updated as new information becomes available. Our peer review process typically takes one to six weeks depending on the issue.