Effects of anemia in chronic kidney disease
- Jeffrey S Berns, MD
Jeffrey S Berns, MD
- Editor-in-Chief — Nephrology
- Section Editor — Dialysis
- Professor of Medicine
- Perelman School of Medicine at the University of Pennsylvania
- Section Editors
- Steve J Schwab, MD
Steve J Schwab, MD
- Editor-in-Chief — Nephrology
- Section Editor — Dialysis
- University of Tennessee Health Science Center
- Gary C Curhan, MD, ScD
Gary C Curhan, MD, ScD
- Section Editor — Chronic Kidney Disease
- Professor of Medicine
- Harvard Medical School
Anemia is common among patients with chronic kidney disease (CKD). In addition to causing disabling symptoms, severe anemia may affect cardiovascular function in nondialysis CKD and dialysis patients. Among nondialysis CKD patients, severe anemia may accelerate the progression to end-stage renal disease (ESRD).
This topic reviews the effects of anemia on cardiovascular dysfunction, particularly left ventricular hypertrophy (LVH) and heart failure (HF), and on the progression of kidney dysfunction in CKD patients.
Other signs and symptoms of anemia (which are the same in CKD patients as among individuals without kidney disease) are discussed elsewhere. (See "Approach to the adult patient with anemia", section on 'Clinical consequences' and "Anemia in the older adult", section on 'Functional outcomes'.)
The treatment of anemia among CKD patients is discussed elsewhere. (See "Treatment of anemia in nondialysis chronic kidney disease" and "Treatment of anemia in hemodialysis patients" and "Treatment of anemia in peritoneal dialysis patients".)
Cardiovascular disease is a major cause of morbidity and mortality in patients with CKD, including those undergoing maintenance dialysis . Even patients with mild CKD have a greater burden of prevalent cardiovascular disease compared with similar age controls . (See "Chronic kidney disease and coronary heart disease" and "Myocardial dysfunction in end-stage renal disease".)
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