Medline ® Abstract for Reference 20
of 'Effect of hormonal contraceptives and postmenopausal hormone therapy on blood pressure'
20
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Hormone replacement therapy and 24-hour blood pressure profile of postmenopausal women.
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Butkevich A, Abraham C, Phillips RA
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Am J Hypertens. 2000;13(9):1039.
Menopause is associated with an increase in blood pressure (BP) and a decrease in physiologic nocturnal BP fall. These factors may play a role in the increased risk of cardiovascular events after menopause. Some studies indicate that transdermal estrogen replacement therapy may help restore the 24-h BP profile, but data on the effect of oral conjugated estrogens are lacking. We compared 24-h ambulatory BP profiles of 42 postmenopausal women not receiving hormone replacement therapy (HRT) and 20 women receiving HRT. HRT was associated with a significant increase in the proportion of dippers (50% in women not receiving HRT and 80% in women receiving HRT, P = .048). Increase in nocturnal dipping may account, in part, for the beneficial cardiovascular effects of HRT.
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Zena and Michael A. Wiener Cardiovascular Institute and Department of Medicine, Mount Sinai Medical Center, New York, New York 10029, USA.
PMID