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Effect of herpes simplex virus on HIV infection: Implications for HIV prevention

Authors
Christine Johnston, MD, MPH
Anna Wald, MD, MPH
Section Editor
Martin S Hirsch, MD
Deputy Editor
Jennifer Mitty, MD, MPH

INTRODUCTION

Herpes simplex virus type 2 (HSV-2) infection is highly prevalent among HIV-infected patients. Whether this association results from similar modes of acquisition or to biologic interactions between the two viruses has been a topic of intense debate.

This topic will address interactions between HIV and HSV-2 and the implications for HIV prevention. The natural history, clinical manifestations, diagnosis, and treatment of genital HSV infection in the HIV-infected host are discussed elsewhere. (See "Treatment of genital herpes simplex virus type 2 in HIV-infected patients" and "Epidemiology, clinical manifestations, and diagnosis of genital herpes simplex virus in HIV-infected patients".)

EPIDEMIOLOGY

The discussion below addresses the effect of HSV-2 infection on HIV acquisition and transmission.

HIV acquisition — Several lines of evidence suggest that prevalent and incident HSV-2 infections increase the risk of HIV acquisition.

Prevalent HSV-2 infection — Epidemiologic studies have shown that HSV-2-seropositive persons have a two- to threefold increased risk of acquiring HIV infection compared with HSV-2-seronegative persons [1-5].

                    

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Literature review current through: Nov 2016. | This topic last updated: Thu Apr 23 00:00:00 GMT+00:00 2015.
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