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Effect of diuretics on magnesium handling by the kidney

Alan S L Yu, MB, BChir
Sri G Yarlagadda, MD
Section Editor
Richard H Sterns, MD
Deputy Editor
Albert Q Lam, MD


Approximately 2.5 g of magnesium (100 mmol) is filtered by the glomerulus every day. Under normal conditions, 95 percent of the filtered magnesium is reabsorbed, and 5 percent is excreted. Reabsorption of magnesium occurs via both paracellular and transcellular processes. (See "Regulation of magnesium balance".)

Diuretics are widely used in the treatment of hypertension, heart failure, cirrhosis, and kidney diseases. Three types of diuretics are known to influence magnesium homeostasis:

Loop diuretics

Thiazide-type diuretics

Potassium-sparing diuretics

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Literature review current through: Nov 2017. | This topic last updated: May 12, 2017.
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