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Drug reaction with eosinophilia and systemic symptoms (DRESS)

Author
Jean-Claude Roujeau, MD
Section Editor
Maja Mockenhaupt, MD, PhD
Deputy Editor
Rosamaria Corona, MD, DSc

INTRODUCTION

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, potentially life-threatening, drug-induced hypersensitivity reaction that includes skin eruption, hematologic abnormalities (eosinophilia, atypical lymphocytosis), lymphadenopathy, and internal organ involvement (liver, kidney, lung) [1-3].

DRESS is characterized by a long latency (two to eight weeks) between drug exposure and disease onset, a prolonged course with frequent relapses despite the discontinuation of the culprit drug, and frequent association with the reactivation of a latent human herpesvirus infection.

DRESS will be reviewed in this topic. Other types of cutaneous drug reactions, drug fever, and drug allergy are discussed separately.

(See "Drug eruptions".)

(See "Exanthematous (morbilliform) drug eruption".)

                                   

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Literature review current through: Nov 2016. | This topic last updated: Mon May 23 00:00:00 GMT 2016.
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References
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