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Drug-induced thrombosis in patients with malignancy

Kenneth A Bauer, MD
Section Editor
Lawrence LK Leung, MD
Deputy Editor
Jennifer S Tirnauer, MD


Cancer is often associated with hypercoagulability due to changes in coagulation factors, local venous stasis, surgery, and the presence of a central venous catheter. In addition, chemotherapy drugs may further increase the risk of thromboembolic disease. This topic discusses the thrombotic complications associated with cytotoxic chemotherapy and some biologic agents (eg, hormonal therapy, thalidomide analogs). Additional topic reviews discuss the following:

Other causes of thrombosis in patients with cancer:

Antiangiogenic cancer therapies – (See "Toxicity of molecularly targeted antiangiogenic agents: Cardiovascular effects", section on 'Arterial and venous thromboembolism'.)

Erythropoiesis-stimulating agents – (See "Role of erythropoiesis-stimulating agents in the treatment of anemia in patients with cancer", section on 'Thromboembolic risk'.)

Tumor-associated hypercoagulability – (See "Pathogenesis of the hypercoagulable state associated with malignancy".)

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Literature review current through: Nov 2017. | This topic last updated: Jun 23, 2017.
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