Medline ® Abstract for Reference 25

of 'Drug eruptions'

25
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Antigen identification in drug-induced bullous pemphigoid.
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Smith EP, Taylor TB, Meyer LJ, Zone JJ
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J Am Acad Dermatol. 1993;29(5 Pt 2):879.
 
Immunobullous diseases usually develop spontaneously, but drug-induced bullous disease develops in a small subgroup of patients. We examined a patient in whom bullous pemphigoid developed after she received enalapril for treatment of hypertension. IgG antibody directed against a 230 kd antigen was identified. The eluted IgG autoantibody was shown to bind to the basement membrane zone on split skin. This study demonstrates that drug-induced bullous pemphigoid autoantibody in this patient was directed against the same antigen as the spontaneous bullous pemphigoid antigen.
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Department of Internal Medicine, Veterans Affairs Medical Center, Salt Lake City, UT.
PMID