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Medline ® Abstract for Reference 27
of 'Dissociative aspects of posttraumatic stress disorder: Epidemiology, clinical manifestations, and diagnosis'
27
TI
Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation.
AU
Lanius RA, Williamson PC, Densmore M, Boksman K, Gupta MA, Neufeld RW, Gati JS, Menon RS
SO
Am J Psychiatry. 2001;158(11):1920.
OBJECTIVE:
The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD.
METHOD:
Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging at a 4-T field strength.
RESULTS:
PTSD subjects showed significantly less activation of the thalamus, the anterior cingulate gyrus (Brodmann's area 32), and the medial frontal gyrus (Brodmann's area 10/11) than did the comparison subjects.
CONCLUSIONS:
The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.
AD
Department of Psychiatry, University of Western Ontario, London, Canada. ruth.lanius@lhsc.on.ca
PMID