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Disorders of ventilatory control

Author
Douglas C Johnson, MD
Section Editor
Scott Manaker, MD, PhD
Deputy Editors
Helen Hollingsworth, MD
April F Eichler, MD, MPH

INTRODUCTION

The respiratory system is dependent upon a complex system of ventilatory control to ensure appropriate and adequate ventilation in order to supply oxygen, remove carbon dioxide, and maintain acid-base homeostasis. Respiratory centers in the brain integrate input from neural and chemical receptors and provide neuronal drive to the respiratory muscles, which maintain upper airway patency and drive the thoracic bellows to determine the level of ventilation.

The abnormalities of ventilatory control that result from a variety of disorders, including chronic obstructive pulmonary disease (COPD), asthma, Ondine's curse, carotid body resection, Cheyne-Stokes respiration, myxedema, starvation, and neuromuscular disease, will be reviewed here. In addition, the effects of several pharmacologic agents on ventilation and ventilatory control will be reviewed. The physiologic aspects of ventilatory control and the evaluation of patients with disorders of ventilation are discussed separately. (See "Control of ventilation".)

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Development of hypercapnia is inconsistent among patients with chronic obstructive pulmonary disease (COPD) and similar degrees of airflow obstruction. COPD patients exhibiting the "blue bloater" profile of hypercapnia (CO2 retention, ie, elevated arterial carbon dioxide tension [PaCO2]) and hypoxemia have decreased respiratory drive compared with "pink puffers," who are eucapnic and have relatively normal oxygen levels [1,2].

The pattern of breathing in patients with chronic CO2 retention is characterized by a low tidal volume and high frequency, usually ≥22 breaths/minute. This respiratory pattern in combination with impaired matching of ventilation and perfusion leads to increased dead space ventilation and diminished alveolar ventilation, which contributes to CO2 retention [3].

Some hypercapnic, hypoxemic patients with COPD develop increased CO2 retention when O2 is administered. Such patients usually have both blunted hypercapnic and hypoxic drives [4]. Other factors contributing to CO2 retention during O2 breathing include worsening of ventilation-perfusion distribution secondary to relief of compensatory pulmonary vasoconstriction [5], and unloading of CO2 due to the Haldane effect [6]. (See "The evaluation, diagnosis, and treatment of the adult patient with acute hypercapnic respiratory failure".)

                     

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Literature review current through: Nov 2016. | This topic last updated: Tue Jan 26 00:00:00 GMT+00:00 2016.
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