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Disorders of fibrinogen

Caroline Bérubé, MD
Section Editor
Lawrence LK Leung, MD
Deputy Editor
Jennifer S Tirnauer, MD


Fibrinogen plays a pivotal role in normal hemostasis as a substrate for conversion to fibrin, a support for thrombin generation and platelet aggregation, and a facilitator of wound healing. Fibrin also forms a template for subsequent fibrinolysis and wound healing. A number of inherited and acquired fibrinogen disorders have been described; these can have both hemorrhagic and thrombotic manifestations, as well as effects on pregnancy, depending on the specific defect.

This topic describes the pathophysiology, clinical presentation, diagnosis, and treatment of inherited and acquired fibrinogen disorders.

Separate topic reviews discuss other disorders of hemostasis and thrombosis:

Other rare inherited coagulation factor disorders – (see "Rare inherited coagulation disorders" and "Factor XI deficiency")

Hemophilia – (see "Clinical manifestations and diagnosis of hemophilia")

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Literature review current through: Sep 2017. | This topic last updated: Aug 28, 2017.
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